Anti-tumor platinum complexes, their preparation and their thera

Details Anti-tumor platinum complexes, their preparation and their thera Anti-tumor platinum complexes, their preparation and their thera

1995-06-07

1997-05-27

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540201, A61K 31555, C07F 1500, C07D20508, C07D207277

Patent

active

056332432

ABSTRACT:
Compounds of formula (I): ##STR1## in which: A and B are separately monoamines or together diamines; and Z is a group of formula (II) or (III): ##STR2## (in which R.sup.1, R.sup.2 and R.sup.7 are various organic groups, n is 0, 1 or 2 and X is a direct carbon-carbon bond or lower alkylene) show valuable anti-tumor activity and may be prepared by reacting an amine-platinum complex with a compound providing the group represented by Z.

REFERENCES:
patent: 4169846 (1979-10-01), Kidani et al.
Rosenberg et al, "Platinum Compounds", Nature, 222, 385-386 (1965).
Yoshinori Kidani et al, "Antitumor Activity of Platinum (II) Complexes of 1,2-Diaminocyclohexane Isomers", Gann, 71, 637-643 (1980).
Drugs of the Future, "Carboplatinum", 8, (6) 489-491 (1983).
Pazdur, "Proc. Am. Soc. Clin. Oncol." 3, p. 219 #C-856 (1984).
Martin, Cancer Research 46, 2189 (1986).
Estey, Cancer, Treat. Reports 70, pp. 1105-1115 (1986).
Zee-Cheng, Meth and Find Expl Clin Pharmacol 10 (1988), pp. 67-71 only.
Schilder, Cancer Res, 54, 709-717 (1994).
Prestayko, "Cisplatin" (AP, 1980) pp. 183-191.
Winogrud, "The Nude Mouse in Oncology Research" (CRC Press, 1991) pp. 305-316.
Kolata, N.Y. Times Jul. 26, 1994, p. C3.
Dermer, Biol. Technology, 12 Mar. 1994, p. 320.
Martin, Cancer. Treat. Reports, 68, p. 1317 (1984).

Affiliated with

Also associated with

Rating

Anti-tumor platinum complexes, their preparation and their thera does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Anti-tumor platinum complexes, their preparation and their thera, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-tumor platinum complexes, their preparation and their thera will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2329181