Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-10-24
2006-10-24
Campell, Bruce R. (Department: 1648)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S300000, C530S350000, C530S402000, C424S094100, C435S069100, C435S069700
Reexamination Certificate
active
07125839
ABSTRACT:
Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or organism are described. The pathogen-detection domain and effector domain of the chimeric molecules are domains not typically found in nature to be associated together. Agents are also described herein having at least one pathogen-interacting molecular structure and at least one effector-mediating molecular structure, the agent being one that is non-naturally-occurring in a cell. The methods of prevention and treatment described herein are effective for a broad spectrum of pathogens and exhibit little or no toxic side-effects. Assays for the detection of a pathogen, pathogen component, or product produced or induced by a pathogen, are also provided.
REFERENCES:
patent: 5561222 (1996-10-01), Keene et al.
patent: 5976800 (1999-11-01), Lau et al.
patent: 5989886 (1999-11-01), Boeke et al.
patent: 5990388 (1999-11-01), Roth et al.
patent: 6037461 (2000-03-01), Alnemri
patent: 6074636 (2000-06-01), Nichols
patent: 6221355 (2001-04-01), Dowdy
patent: 6319500 (2001-11-01), Goldenberg
patent: 6326466 (2001-12-01), Bottaro et al.
patent: 6416785 (2002-07-01), Riesenberg et al.
patent: 2003/0054000 (2003-03-01), Dowdy
Ashorn et al., Proceedings of the National Academy of Sciences, USA, vol. 87 No. 22, pp. 8889-8893 (Nov. 1990).
Tse et al., Proceedings of the National Academy of Sciences, vol. 97 No. 22, pp. 12266-12271 (Oct. 2000).
Berlin et al., Proceedings of the National Academy of Sciences, USA, vol. 94, pp. 1172-1176 (Feb. 1997).
Inohara et al., Proceedings of the National Academy of Sciences, USA, vol. 94, pp. 10717-10722 (Sep. 1997).
Kaufmann et al., FEBS Letters, vol. 527, pp. 250-254 (Sep. 2002).
Thornberry et al., Science, vol. 281, pp. 1312-1316 (Aug. 1998).
Wolf et al., The Journal of Biological Chemistry, vol. 274, pp. 20049-20052 (Jul. 1999).
Allgood, Victoria E. and Eastman, Eric M., “Chimeric Receptors as Gene Switches,”Curr. Opin. in Biotech.8(4):474-479 (1997).
Aqeilan, Rami et al., “Interleukin 2-Bax:A Novel Prototype of Human Chimeric Proteins for Targeted Therapy,”FEBS Letters, 457:271-276 (1999).
Azar, Y and Loberbourn-Galeski, H.., “GbRH-Bik/Bax/Bak Chimeric Proteins Target and Kill Adenocarcinoma Cells; The General Use of Pro-Apoptotic Proteins of the Bcl-2 Family as Novel Killing Components of Targeting Chimeric Proteins,”Apoptosis, 5:531-542 (2000).
Boeke, Jef D. and Hahn, Beatrice, “Destroying Retroviruses from Within,”Trends in Microbiology, 4(11):421-426 (1996).
Finlay, B. Brett and Cossart, Pascale, “Exploitation of Mammalian Host Cell Functions by Bacterial Pathogens,”Science, 276:718-725 (1997).
Bukrinsky, Michael I. and Haffar, Omar K., “HIV-1 Nuclear Import: In Search of a Leader,”Frontiers in Bioscience, 4:d772-781 (1999).
Chen, Qi et al., “Structure-Based Discovery of lIgands Targeted to the RNA Double Helix,”Biochemistry36:11402-11407 (1997).
Fan, Liangfen et al., “Improved Artificial Death Switches Based on Caspases and FADD,”Human Gene Therapy10:2273-2285 (1999).
Friedler, Assaf et al., “Backbone Cyclic Peptide, Which Mimics the Nuclear Localization Signal of Human Immunodeficiency Virus Type 1 Matrix Protein, Inhibits Nuclear Import and Virus Production in Nondividing Cells,”Biochemistry37:5616-5622 (1998).
Gao, Lian-Young and Kwaik, Yousef Abu, “Hijacking of Apoptotic Pathways by Bacterial Pathogens,”Microbes and Infection, 2:1705-1719 (2000).
Gao, Lin-Young and Kwaik, Yousef Abu, “The Modulation of Host Cell Apoptosis by Intracellular Bacterial Pathogens,”Trends in Microbiology8(7):306-313 (2000).
Greenberg, Steven J. et al., “Pleiotropic Expression of Heterologous Cytokine/Receptor Genes in HTLV-1 Associated Diseases: Candidate TRS for Chimeric Gene Therapy,”Leukemia, 11(Suppl. 3):79-81 (1997).
Knodler, Leigh A. et al., “Pathogenic Trickery: Deception of Host Cell Processes,”Nature Reviews Molecular Cell Biology, 2(8):578-588 (2001).
MacCorkle, Rebecca A. et al., “Synthetic Activation Caspases: Artificial Death Switches,”Proc. Natl. Acad. Sci. USA, 95:3655-3660 (1998).
Müller, Anne and Rudel, Thomas, “Modification of Host Cell Apoptosis by Viral and Bacterial Pathofens,”Int. J. Med Microbiol.291:197-207 (2001).
Popov, Serguei et al., “Critical Role of Reverse Transcriptase in the Inhibitory Mechanism of CNI-H0294 on HIV-A Nuclear Translocation,”Proc. Natl. Acad. Sci. USA, 93:11859-11864 (1996).
Schwarze, Steven R. et al., “In Vivo Protein Transduction; Delivery of a Biologically Active Protein into the Mouse,”Science, 285:1569-1572 (1999).
Shariat, Shahrokh F. et al., “Adenovirus-mediated Transfer of Inducible Caspases: A Novel “Death Switch” Gene Therapeutic Approach to Prostate Cancer,”Cancer Research, 61(6):2562-2571 (2001).
Thomis, Daniel C. et al., “A Fas-based Suicide Switch in Human T Cells for the Treatment of Graft-Versus-Host Disease,”Blood, 97(5):1249-1257 (2001).
Vocero-Akbami, Adita M. et al., “Killing HIV-Infected Cells by Transduction with an HIV Protease-Activated Caspase-3 Protein,”Nature Medicine, 5(1):29-33 (1999).
Sakamoto, Kathleen M., et al., “Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F boc complex for ubiquitination and degradation,”Proc. Natl. Acad. Sci. USA98:8554-8559 (2001).
Wainwtight, Mark, “Photodynamic antimicrobial chemotherapy (PACT),”J. Antimicrobial Chemotherapy42:13-28 (1988).
Devanathan, S., et al., “Readily available fluorescein isothiocyanate-conjugated antibodies can be easily converted into targeted phototoxic agents for antibacterial, antiviral, and anticancer therapy,”Proc. Natl. Acad. Sci. USA87:2980-2984 (1990).
Qian, Xiao-Yan, et al., “New approach for inhibiting REV function and HIV-1 production using the influenza virus NSI protein,”Proc. Natl. Acad. Sci. USA83:8873-8877 (1996).
Nagata, Shigekazu, “Apoptosis By Death Factor,”Cell88:355-365 (1997).
Nuñez, Gabriel, et al., “Caspases: the Proteases of the Apoptotic Pathway,”Oncogene 17: 3237-3245 (1998).
Hu, Shimin, et al., “Capase-14 Is a Novel Developmentally Regulated Protease,”J. Bio. Chem., 273(45):29648-29653(1998).
Campell Bruce R.
Hamilton Brook Smith & Reynolds P.C.
Lucas Zachariah
Massachusetts Institute of Technology
LandOfFree
Anti-pathogen treatments does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-pathogen treatments, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-pathogen treatments will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3631743