Anti-marinobufagenin antibodies and methods for their use

Details Anti-marinobufagenin antibodies and methods for their use Anti-marinobufagenin antibodies and methods for their use

2006-06-26

2011-10-18

Gambel, Phillip (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S130100, C424S133100, C424S141100, C424S152100, C424S172100, C435S007200, C530S387100, C530S387300, C530S388100, C530S388200, C530S388240

Reexamination Certificate

active

08038997

ABSTRACT:
Described herein are deposited hybridoma cell lines and the monoclonal antibodies produced by these hybridomas, and antigen binding fragments thereof. These monoclonal antibodies and antigen binding fragments specifically bind marinobufagenin. The disclosure also encompasses the use of these monoclonal antibodies or antigen binding fragments in a method for detecting the presence of marinobufagenin in a biological sample. Also provided are methods for the use of these monoclonal antibodies or antigen binding fragments as prophylactic, therapeutic, and diagnostic agents for the detection, inhibition and treatment of a cardiovascular disease, for example, essential hypertension, hypertension associated with preeclampsia, eclampsia, or renal failure, or myocardial fibrosis in a subject.

REFERENCES:
patent: 5770376 (1998-06-01), Bagrov
patent: 2004/0018201 (2004-01-01), Adair
patent: 2004/0018202 (2004-01-01), Adair
patent: 2004/011028 (2004-02-01), None
patent: 2004/071273 (2004-08-01), None
The Merck Manual of Medical Diagnosis and Therapy, Seventeenth Edition edited by Beers et al., Merck Research Laboratories, Whitehouse Station, NJ 1999; pp. 1629-1648; 2057-2058.
Fedorova et al., J Hypertens 26: 2414-2425, 2008.
Kolmakova et al., Nephrol Dial Transplant Feb. 2011 [Epub ahead of print] PubMed PMID: 21292813.
Tian et al., Hypertension 56(5): 914-919, 2010.
Nikitina et al., J Hypertens Feb. 16, 2011 [Epub ahead of print] PubMed PMID: 21330936.
Bagrov et al., “Antiarrhythmic Effect of Antibodies to Digoxin in Acute Myocardial Ischemia in Rats,”European Journal of Pharmacology, 162:195-196, 1989.
Fedorova et al., “Antibody to Marinobufagenin Lowers Blood Pressure in Pregnant Rats on a High NaCl Intake,”Journal of Hypertension, 23(4):835-842, Apr. 2005, abstract.
Fedorova et al., “Endogenous Ligand of Alphal Sodium Pump, Marinobufagenin, Is a Novel Mediator of Sodium Chloride-Dependent Hypertension,”Circulation, 105(9):1122-1127, Mar. 2002, abstract.
Goodlin, Robert C., M.D., “Antidigoxin Antibodies in Eclampsia,”The New England Journal of Medicine, pp. 518-519, 1988.
Kennedy et al., “Hypertension: Central Role for the Cardiotonic Steroid Marinobufagenin in the Pathogenesis of Experimental Uremic Cardiomyopathy,”Journal of the American Heart Association, pp. 488-495, 2006.
Lopatin et al., “Circulating Bufodienolide and Cardenolide Sodium Pump Inhibitors in Preeclampsia,”Journal of Hypertension, 17(8):1179-1187, Aug. 1999.
Menezes et al., “Digoxin Antibody Decreases Natriuresis and Diuresis in Cerebral Hemorrhage,”Intensive Care Med, 29:2291-2296, 2003.
Schoner, Wilhelm, “Endogenous Cardiac Glycosides, A New Class of Steroid Hormones,”Eur. J. Biochem, 269:2440-2448, 2002.
Steyn et al., “Bufadienolides of Plant and Animal Origin,”Natural Product Reports, pp. 397-413, 1998.

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