Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-02-15
2011-02-15
Powers, Fiona T (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S234000
Reexamination Certificate
active
07888357
ABSTRACT:
A novel class of pyridazine compositions and related methods of use.
REFERENCES:
patent: 2857384 (1958-10-01), Druey et al
patent: 4169158 (1979-09-01), Laborit et al.
patent: 4508720 (1985-04-01), Kan et al.
patent: 4710499 (1987-12-01), Wermuth et al.
patent: 4721711 (1988-01-01), Chambon et al.
patent: 4977152 (1990-12-01), Biziere et al.
patent: 5045541 (1991-09-01), Nakao et al.
patent: 5484940 (1996-01-01), Grant et al.
patent: 2003/0176437 (2003-09-01), Watterson et al.
patent: 2006/0073472 (2006-04-01), Watterson et al.
patent: 2008/0021035 (2008-01-01), Watterson et al.
patent: 2008/0318899 (2008-12-01), Watterson et al.
patent: 2009/0029985 (2009-01-01), Watterson et al.
patent: 0072726 (1983-02-01), None
patent: 0072726 (1983-02-01), None
patent: 0211457 (1987-02-01), None
patent: 0211457 (1987-02-01), None
patent: 0382634 (1990-08-01), None
patent: 0382634 (1990-08-01), None
patent: 0628550 (1994-12-01), None
patent: 0628550 (1994-12-01), None
patent: 1061077 (2000-12-01), None
patent: 1061077 (2000-12-01), None
patent: 2141697 (1973-01-01), None
patent: 2141697 (1973-01-01), None
patent: 2847253 (2004-05-01), None
patent: 2847253 (2004-05-01), None
patent: 9846574 (1998-10-01), None
patent: WO 98/46574 (1998-10-01), None
patent: 0142241 (2001-06-01), None
patent: WO 01/42241 (2001-06-01), None
patent: 0222605 (2002-03-01), None
patent: WO 02/22605 (2002-03-01), None
patent: 03018563 (2003-03-01), None
patent: WO 03/018563 (2003-03-01), None
patent: PCTEP2003047577 (2003-06-01), None
patent: WO 03/047577 (2003-06-01), None
patent: 2004046117 (2004-06-01), None
patent: WO 2004/046117 (2004-06-01), None
patent: 2005009976 (2005-02-01), None
patent: WO 2005/009976 (2005-02-01), None
patent: 2005061509 (2005-07-01), None
patent: 2005063761 (2005-07-01), None
patent: WO 2005/061509 (2005-07-01), None
patent: WO 2005/063761 (2005-07-01), None
patent: 2006026135 (2006-03-01), None
patent: WO 2006/026135 (2006-03-01), None
patent: 2006050359 (2006-05-01), None
patent: 2006050389 (2006-05-01), None
patent: WO 2006/050359 (2006-05-01), None
patent: WO 2006/050389 (2006-05-01), None
patent: 2007127375 (2007-04-01), None
patent: WO 2007/127375 (2007-04-01), None
patent: WO 2007/127475 (2007-04-01), None
patent: WO 2007/130383 (2007-04-01), None
patent: WO 2007/127448 (2007-11-01), None
patent: WO 2007/127474 (2007-11-01), None
patent: WO 2008/109437 (2008-09-01), None
C. Wermuth, et al.: “3-Aminopyridazine Derivatives with Atypical Antidepressant, Serotonergic, and Dopaminergic Activities” Journal of Medicinal Chemistry., vol. 32, No. 3, 1989, pp. 528-537. USAmerican Chemical Society, Washington. Tables 1, 3-5.
Salida Mirzoeva, et al.: “Discovery of a 3-Amino-6-phenyl-pyridazine Derivative as a New Synthetic Antineuroinflammatory Compound.” Journal of Medicinal Chemistry., 2002 vol. 45, No. 3, pp. 563-566 USAmerican Chemical Society, Washington. pp. 563-564.
Watterson, DM; Mirzoeva, S. Guo, L; Whyte, A; Bourguignon, JJ; Hibert, M; Haiech, J; and Van Eldik, LJ; Ligand Modulation of Glial Activation: Cell Permeable, Small Molecule Inhibitors of Serine-Threonine Protein Kinases Can Block Induction of Interleukin 1β and Nitric Oxide Synthase II; Neurochemistry International, 2001, 459-468, vol. 39.
Wermuth, CG; Bourguignon, JJ; Schlewer, G; Gies, JP; Schoenfelder, A; Melikian, A; Bouchet, MJ; Chantreux, D; Molimard, JC; Heaulme, M; Chambron, JP; and Biziere, K; Synthesis and Structure-Activity Relationships of a Series of Aminopyridazine Derivatives of γ-Aminobutyric Acid Acting as Selective GABA-A Antagonists; Journal of Medicinal Chemistry, 1987, 239-249, vol. 30, No. 2.
Chitaley, K; Wingard, CJ; Webb, RC; Branam, H; Stopper, VS; Lewis, RW; and Mills, TM; Antagonism of Rho-kinase Stimulates Rat Penile Erection Via A Nitric Oxide-Independent Pathway; Nature Medicine, Jan. 2001, 119-122, vol. 7, No. 1.
Toma, L; Quadrelli, P; Bunnelle, WH; Anderson, DJ, Meyer, MD; Cignarella, G; Gelain, A; and Barlocco, D; 6-Chloropyridazin-3-yl Derivatives Active as Nicotinic Agents: Synthesis Binding, and Modeling Studies; Journal of Medicinal Chemistry, J. Med. Chem., 2002, 4011-4017, 45 (18).
Watterson, DM; Haiech, J; and Van Eldik, LJ; Discovery of New Chemical Classes of Synthetic Ligands that Suppress Neuroinflammatory Responses; Journal of Molecular Neuroscience; 2002, 89-93, vol. 19.
Schumacher, A; Velentza, AV; and Watterson, DM; Death Associated protein Kinase as a Potential Therapeutic Target; Ashley Publications; Aug. 2002, 497-506 vol. 6, No. 4; Ashley Publications.
Velentza, AV; Schumacher, AM; and Watterson, DM; Structure, Activity, Regulation, and Inhibitor Discovery for a Protein Kinase Associated with Apoptosis and Neuronal Death; Pharmacology & Therapeutics, 2002, 217-224, vol. 93.
Velentza, AV; Schumacher, AM; Weiss, C; Egli, M; and Watterson, DM; A protein Kinase Associated with Apoptosis and Tumor Suppression : Structure, Activity, and Discovery of Peptide Substrates; Journal of Biological Chemistry, Oct. 19, 2001, 38956-38965, vol. 276, Issue 42.
Kumar, CC and Madison V; Drugs Targeted Against Protein Kinases; Expert Opinion, Oct. 2001, 303-315, vol. 6, No. 2; Ashley Publications.
Guo, L; Sawkar, A; Zasadzki M; Watterson, DM, and Van Eldik, LJ; Similar Activation of Glial Cultures from Different Rat Brain Regions by Neuroinflammatory Stimuli and Downregulation of the Activation by a New Class of Small Molecule Ligands; Neurobiol Aging; Nov.-Dec. 2001;975-981, 22(6).
Valentza, AV; Schumacher, AM; Weiss, C; Sawkar, A; Zasadzki, M; Haiech, J; Egli, M; and Watterson, DM; Discovery of Substrates and Small Molecule Inhibitors for a Death Associated Protein Kinase; Cellular & Molecular Biology Letters, International Scientific Journal; 2nd International Conference on Inhibitors of Protein Kinases, Sep. 2001, 484, vol. 6 No. 2B.
Adams et al. (2004) “Concise Synthesis of 1H-pyrazin-2-ones and 2-Aminopyrazines”. Synlett. 11:2031-2033.
Akama et al. (1998) “Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFxB-dependent mechanism”.PNAS. 95:5795-5800.
Akiyama et al. (2000) “Inflammation and Alzheimer's Disease”.Neurobiol Aging. 21:383-421.
Allen and Van Allen, (1951) J. American Chem Society 73:5856.
Apter, et al. (1999) “Buspirone: Future Directions”. J Clin Psychopharmacol. 19:86-93.
Badger, et al. (1996) “Pharmacological Profile of SB 203580, a Selective Inhibitor of Cytokine Suppressive Binding Protein/p38 Kinase, in Animal Models of Arthritis, Bone Resorption, Endotoxin Shock and Immune Function”.J. Pharmacol Exp Ther.279:1453-1461.
Bhagwat, et al. (1999) “Gene-regulating protein kinases as important anti-inflammatory targets” Drug Disc. Today. 4 472-479.
Bhat, et al. (1998) “Extracellular Signal-regulated Kinase and p38 Subgroups of Mitogen-Activated Protein Kinases Regulate Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-alpha Gene Expression in Endotoxin-Stimulated Primary Glial Cultures”. J Neurosci. 18 1633-1641.
Blasi, et al. (1990) “Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus”. J. Neuroimmunol. 27 229-237.
Brott, et al. (2000) “Treatment of acute ischemic stroke”, N Engl J Med. Sep. 7, 2000;343(10):710-22.
Cardona et al. (2006) “Control of microglial neurotoxicity by the fractalkine receptor”. Nature Neurosci. 9:917-924.
Chayer, S et al. (1998) “(3-Pyridazinamin-3-yl) Alpha-Aminoacids: A Facilitated Method of Preparation of Phenylalanine and Proline Representatives”. Tetrahedron Letters. 39:841-844.
Cignarella G, et al. (1989) “Synthesis and biological evaluation of substituted benzo[A]cinnolinones and 3H-benzo[6,7]cyclohepta[I,2- c]pyridazinones: higher homologues of the antihypertensive and antithrombotic 5H-indeno[I,2- c]pyridazinones”.J. Med. Chem.32: 2277-2282.
Contreras et al. (1999) “Aminopyridazines as Acetylcholinesterase Inhibitors”.J. of Med. Chem.42(4):730
Bourguignon Jean-Jacques
Haiech Jacques
Hibert Marcel
Lukas Thomas J.
Mirzoeva Salida
Centre National de la Recherche Scientifique
Millen White Zelano & Branigan P.C.
Northwestern University
Powers Fiona T
Universite de Strasbourg
LandOfFree
Anti-inflammatory and protein kinase inhibitor compositions... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-inflammatory and protein kinase inhibitor compositions..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-inflammatory and protein kinase inhibitor compositions... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2634871