Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2005-05-03
2005-05-03
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S185100, C424S192100, C435S810000, C530S324000
Reexamination Certificate
active
06887472
ABSTRACT:
The present invention provides compositions and methods for the use of antigenic peptides derived from the Fc portion of the epsilon heavy chain of an IgE molecule as vaccines for the treatment and prevention of IgE-mediated allergic disorders. In particular, the invention provides compositions, methods for the treatment and prevention of IgE-mediated allergic disorders comprising an immunogenic amount of one or more antigenic peptides derived from the CH3 domain or junction of Ch-3/CH4 domain of an IgE molecule and methods for the evaluation of IgE mediated allergies in dogs.
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Harlow et al in Antibodies a Laboratory Manual, 1998, Cold Spring harbor laboratory publication, Cold Spring Harbor, NY, p. 129.*
Shakib, et al.; Identification of Peptide Motifs Recognized by a Human IgG Autoanti-IgE antibody Using a Phase Display Library; Clinical and Experimental Allergy; vol. 30 No. 7, pp. 1041-1046 (2000) XP001055645.
Nio, et al.,Inhibition of passive cutaneous anaphylaxis by synthetic human immunoglobulin E peptide fragments, FEBS 11869, vol. 314, No. 3, 229-231 (1992).
Morsey Mohamad A.
Sheppard Michael G.
Wheeler David W.
Ginsburg Paul H.
Huynh Phuong
Kohn & Associates PLLC
Ling Lorraine B.
Pfizer Inc.
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