Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active...
Patent
1995-05-19
1996-11-05
Acquah, Samuel A.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
525420, 525437, 525461, A61K 3174
Patent
active
055715052
ABSTRACT:
The preferred oligomers of the present invention are polyureas, polycarbonates, polyesters or polyamides having a number average molecular weight of <10,000. These oligomers are water-soluble, have a rigid backbone, have recurring units coupled by carbonyl linking moieties which have anionic groups, display predominantly linear geomentry such that regular spacing between anionic groups exists in an aqueous medium, and are pharmaceutically-acceptable. The oligomers are useful for the treatment and/or diagnosis of AIDS and ARC.
REFERENCES:
patent: 2833744 (1958-05-01), Neher
patent: 3528949 (1970-09-01), Rutledge
patent: 3993625 (1976-11-01), Kurihara et al.
patent: 4073768 (1978-02-01), Mark
patent: 4104262 (1978-08-01), Schade
patent: 4312855 (1982-01-01), Grand
patent: 4328244 (1982-05-01), Daniel et al.
patent: 4349568 (1983-09-01), Markley et al.
patent: 4435394 (1994-03-01), Ogata et al.
patent: 4736014 (1988-04-01), Engelhardt et al.
patent: 4824916 (1989-04-01), Kershner et al.
patent: 4895660 (1990-01-01), Kershner et al.
patent: 4966894 (1990-10-01), Herr et al.
patent: 5424063 (1995-06-01), Cardin et al.
R. M. Ottenbrite, ACS Symposium Series #186, pp. 205-220 (1982) "The Antitumor and Antiviral Effects of Polycarboxyl-ic Acid Polymers".
European Chem. News, p. 17 (Jul. 30, 1990).
G. Odian, Principles of Polymerization, 2d, pp. 20-25 (1981).
Ahmed, et al., Antiviral Chemistry & Chemotherapy, (1995) 6(1), 34-42, "Potent Inhibition of Herpes Simplex Virus by MDL101028 a Novel Biphenyl Disulphonic Acid Co-polymer".
Chem. Abstracts, polyamides vol. 102, No. 62707 (1985), Toshiba Corp., Japan, "Block Copolymers" JP 59179521 A2 841012.
Antiviral Research, 18(1992), Sulfonic acid polymers as a new class of human immunodefic-ciency virus inhibitors, Prem Mohan, et al., pp. 139-150.
Komp et al, Chemical Abstracts vol. 110 Abstract No. 33727k (1989).
Cardin et al., "Stilbene Disulfonic Acids. CD4 Antagonists that Block human immunodeficiency Virus Type-1 Growth at Multiple Stages of the Viral Like Cycle" J. Biol. Chem (1991), 266(20), 13355-63.
Hofferek et al., Chemical Abstracts vol. 114:180333q (1990).
Akerfeldt, et al, Chemical Abstracts vol. 75: 72945H (1971).
Taylor et al, "Potent Inhibition of Human Immunodeficiency Virus (HIV) by MDL 101028, a Novel Supphonic Acid Polymer".
Berge et al., J Pharm. Sciences 66 (1), pp. 1-19.
Antiviral Research, 19 (1992), Sulfonic acid polymers as a new classs of human immunodeficiency virus inhibitors, Prem Mohan, et al., pp. 139-150.
Cardin Alan D.
Jackson Richard L.
Mullins Michael J.
Acquah Samuel A.
Kimble Karen L.
Merrell Pharmaceuticals Inc.
Svoboda Craig G.
The Dow Chemical Company
LandOfFree
Anti-HIV oligomers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Anti-HIV oligomers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Anti-HIV oligomers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2013157