Anti-herpesvirus compounds and methods for identifying, making a

Details Anti-herpesvirus compounds and methods for identifying, making a Anti-herpesvirus compounds and methods for identifying, making a

1996-12-04

2000-05-02

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548190, 548146, 548193, 514438, 514447, C07D27700, C07D27704, A61K 3138

Patent

active

060574518

ABSTRACT:
This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.

REFERENCES:
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patent: 4746669 (1988-05-01), Caldwell
patent: 5077409 (1991-12-01), Wissner
Liebig et al., Arznem.-Forch. (Drug Res.) 24, Nr. 6 (1974), pp. 887-892.
Dicker et. al., Antiviral Research, 28, (1995), 213-224.
Y. Kawamatsu et al., "2-Amino-4-Phenylthiazole Derivatives as Anti-Atherogenic Agents", Eur. J. Med. Chem., 16, pp. 355-362 (1981).
J.A. Lowe et al., "1-Naphthylpiperazine Derivatives as Potential Atypical Antipsychotic Agents", J. Med. Chem., 34, pp. 1860-1866 (1991).
C. Selway et al., "Parallel-Compound Synthesis: Methodology for Accelerating Drug Discovery", Bioorganic and Medicinal Chemistry, 4, pp. 645-654 (1996).
Chemical Abstracts, vol. No. 110, page No. 716, Abstract No. 135227 (1986).

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