Anti hepatitis C virus antibody and uses thereof

Details Anti hepatitis C virus antibody and uses thereof Anti hepatitis C virus antibody and uses thereof

2005-10-04

2005-10-04

Housel, James (Department: 1648)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

C424S141100, C424S142100, C424S131100, C424S135100, C424S139100, C424S161100, C435S004000, C435S005000, C435S007100, C435S069100

Reexamination Certificate

active

06951646

ABSTRACT:
Described are novel antibodies specifically recognizing conformation dependent epitopes of HCV glycoprotein E2 and that are capable aof neutralizing the binding of E2 protein onto susceptible cells. Furthermore, antigens and epitopes recognized by the above-described antibodies as well as polynucleotides encoding said antibodies are provided. Also provided are to vectors comprising said polynucleotides as well as host cells transformed therewith and their use in the production of said antibodies. In addition, pharmaceutical and diagnostic compositions are provided comprising any of the aforedescribed antibodies, antigens, epitopes, polynucleotides, vectors or cells. Further described is the use of the aforementioned antibodies, antigens, polynucleotides and vectors in adoptive immunotherapy, preferably for the treatment or prevention of HCV infection during liver transplantation.

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