Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-11-03
1999-04-06
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514297, A61K 3170, A61K 3144
Patent
active
058918647
ABSTRACT:
The present invention relates to an anti-cancer composition containing acridine derivatives and guanosine compounds. In the composition of the present invention, the acridine derivative and the guanosine compound are present in the weight ratio of 1:0.1-5.0, preferably 1:0.3-3.0 and more preferably 1:0.5-1.5. In the composition of the present invention, most preferably the acridine derivative is acriflavine neutral and the guanosine compound is guanosine hydrate. Although acridine derivatives and guanosine compounds used as an active ingredient in the present composition have substantially no anti-cancer effect when they are used individually, the combination of acriflavine neutral and guanosine hydrate which potentiates the effect of acriflavine neutral, i.e. the composition(AG60) according to the present invention, exhibits reduced toxicity and increased anti-cancer effect in comparison to the use of acriflavine neutral or guanosine hydrate alone.
REFERENCES:
Iigo et al., J. Pharmacobio-Dyn 5(7) 1982 pp. 515-520 (The original veterence to follow in due course).
Dyer, An index of Tumor Chemotherapy, (1949), with, pp. 10-12 and 130 ( No. 3750-3757).
Ahn E Tay
Choi Hee Sook
Han Yung Bok
Hong Eun Kyung
Kim Chun Won
Goldberg Jerome D.
Han Yung Bok
Tae Rim Pharm. Co., Ltd.
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