Anti-cancer activity of Androsace umbellata Merr . extract...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Reexamination Certificate

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07960352

ABSTRACT:
The present invention relates to anAndrosace umbellataMerr. extract having anticancer activity and a triterpene saponin compound isolated therefrom, more particularly to anAndrosace umbellata(Lour.) Merr. extract, triterpene saponin compounds isolated therefrom, saxifragifolin B and saxifragifolin D, which inhibit the growth of cancer cells and induce apoptosis of cancer cells, and thus are useful for preparing a composition for preventing and treating cancers and a method of isolating a triterpene saponin compound from anAndrosace umbellataMerr. extract.

REFERENCES:
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National Cancer Institute, SEER Program “Five Most Common Cancers in Each Racial/Ethnic Group”; available at http://web.archive.org/web/20030309225131/http://seer.cancer.gov/publications/ethnicity/topfive.pdf; published electronically Mar. 9, 2003.
Stephen J. Bloor, Cytotoxic Saponins From New Zealand Myrsine Species, J. Nat. Prod., 57 (10), pp. 1354-1360 (1994).
Jonathan P. Waltho, et al., Structure Elucidation of Two Triterpenoid Tetrasaccharides FromAndrosace saxifragifolia, J. Chem. Soc. Perkin. Trans. I, 98), pp. 1527-1531 (1986).
Bikas C. Pal, et al., New Triterpenoid Pentasaccharides FromAndrosace saxifragifolia, J. Chem. Soc. Perkin. Trans. I, (9), pp. 1963-1967 (1987).

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