Anti-bacterial substituted bridged-diazabicycloalkyl quinolone c

Details Anti-bacterial substituted bridged-diazabicycloalkyl quinolone c Anti-bacterial substituted bridged-diazabicycloalkyl quinolone c

1986-08-19

1989-08-29

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514312, 540472, 540556, 544282, 546123, 546156, A61K 31495, A61K 3144, C07D47108, C07D48708

Patent

active

048617792

ABSTRACT:
Antibacterial compounds have the formula ##STR1## wherein R.sup.1 is hydrogen, a pharmaceutically acceptable cation, or alkyl; A is CH, CF, CCl or N; Y is alkyl, haloalkyl, cyclopropyl, vinyl, methoxy, N-methylamino, p-fluorophenyl, p-hydroxyphenyl or p-aminophenyl; or A is carbon and is taken together with Y and the carbon and nitrogen to which A and Y are attached to form a five to seven membered ring which is optionally substituted; and R.sup.2 is a bridged-diazabicycloalkyl group.

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Clive et al., Mutation Research, vol. 31, p. 17-29 (1973).
Domagala et al., J. Med. Chem. vol. 29, p. 394-404, (1986).
Barrett et al., 27th Interscience Conference on Anti-Microbial Agents And Chemotherapy, p. 249-252 (1987).

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