Anti-allergic esters, acetal ethers, thioethers and nitrogen sub

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514242, 514249, 514253, 514256, 514312, 5142342, 5142345, 5142352, 544127, 544212, 544238, 544333, 544350, 544362, 544363, 544128, 544 581, 544 61, 544 62, 546122, 546155, A61K 31435, C07D 4704

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047941162

ABSTRACT:
Esters, acetal ethers, thioethers and nitrogen substituted derivatives of certain bicyclic compounds are disclosed which are useful as anti-allergic, anti-inflammatory and/or cytoprotective agents and in treatment of hyperproliferative skin disease. Pharmaceutical compositions and methods of treatment employing such compounds are also disclosed.

REFERENCES:
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The Merck Index, 9th. Ed., Merck S Co. Rahway, N.J., p. 144 (1976).
Kappe, et al., Monatshefte fur Chemie, 99, pp. 2157-2166 (1968).
Merchant, et al., Curr. Sci., 49(1), pp. 20-21, (1980); Chem Abst. vol. 92-181059u (1980).
Wittman et al., Z. Naturforsch., B: Anorg. Chem., Org. Chem., 33B(12), pp. 1540-1546 (1978); Chem. Abst. vol. 90-121339 (1979).
Bowman, et al., "The Synthesis of Some Dialkylamino-2-quinolones", Journal of the Chemical Society, pp. 1350-1353 (1964).
Suzuki et al., Chemical Pharmaceutical Bulletin, 25 (No. 10) 2602-2607 (1977).

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