Anthracycline compounds

Details Anthracycline compounds Anthracycline compounds

1983-10-25

1985-10-29

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 34, 435 78, A61K 3171, C07H 1524, C12P 1956

Patent

active

045501599

ABSTRACT:
An anthracycline compound, ditrisarubicin, of the formula: ##STR1## wherein R represents one of the following substituents (A), (B), and (C): ##STR2## is produced by a process which comprises cultivating a strain of Streptomyces in a suitable culture medium under aerobic conditions, said strain having the ability to produce the anthracycline compound, ditrisarubicin, and then recovering the anthracycline compound, ditrisarubicin, from the cultured medium. This ditrisarubicin, or an acid addition salt of the ditrisarubicin, can be contained as the active ingredient in antitumor agents and in pharmaceutical compositions for treatment of infections induced by gram-positive microorganisms, whereby good results are attainable.

REFERENCES:
patent: 4316011 (1982-02-01), Oki et al.
patent: 4329339 (1982-05-01), Fujiwara et al.
patent: 4373094 (1983-02-01), Oki et al.
patent: 4386198 (1983-05-01), Oki et al.
patent: 4418192 (1983-11-01), Tanaka et al.
patent: 4424342 (1984-01-01), Oki et al.

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