Angiotension II antagonizing pyridine derivatives

Details Angiotension II antagonizing pyridine derivatives Angiotension II antagonizing pyridine derivatives

1992-04-27

1993-03-30

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514340, 514341, 514344, 514346, 514347, 514348, 514349, 514350, 514351, 544124, 546194, 546256, 546276, 546278, 546287, 546288, 546291, 546293, 546295, 546297, 546298, 546299, 546300, 546301, 546302, C07D40110, A61K 3144

Patent

active

051984393

ABSTRACT:
The invention concerns pharmaceutically useful novel compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

REFERENCES:
patent: 4820843 (1989-04-01), Aldrich et al.
patent: 4880804 (1989-11-01), Carini et al.
G. R. Proctor, et al., J. Chem. Soc., Perkin Trans. I (1972) (14), 1803-8.

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