Angiogenic monoglycerides

Details Angiogenic monoglycerides Angiogenic monoglycerides

1989-03-22

1992-08-11

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Tissue, other than lymphoid tissue

514557, 514549, 514552, 514546, A61K 3119

Patent

active

051377349

ABSTRACT:
Monoglycerides of the formula: ##STR1## wherein R is an aliphatic hydrocarbyl moiety of 2-10 C, straight chain or branched, saturated or unsaturated, and optionally substituted with one or more substituents which do not interfere with angiogenic activity are capable of stimulating angiogenesis in vivo. These compounds, and their pharmaceutical compositions, are useful in wound healing and other therapeutic applications where stimulation of vascularization is beneficial. Antibodies to these materials have also been prepared and are useful in diagnosis and therapy.

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