Analyte separation process and apparatus

Radiant energy – Ionic separation or analysis – With sample supply means

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7386323, 7386481, H01J 4904

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active

054480620

ABSTRACT:
Described are preferred processes and apparatuses for treating samples so as to form conditioned samples for analysis, such as by a mass spectrometer. The apparatuses and processes of the invention include the use of both a membrane separator and a jet separator. This combination of separation techniques results in dramatic and unexpected increases in detection limits.

REFERENCES:
patent: 4791292 (1988-12-01), Cooks et al.
patent: 4883958 (1989-11-01), Vestal
Hoch et al., "A Mass Spectrometer Inlet System for Sampling Gases Dissolved in Liquid Phases", Arch. of Biochem. BIophys., vol. 101, pp. 160-170 (1963).
Bier et al., "Membrane Interface for Selective Introduction of Volatile Compounds Directly Into the Ionization Chamber of a Mass Spectrometer", Anal. Chem., vol. 59, pp. 597-601 (1987).
Slivon et al., "Helium-Purged Hollow Fiber Membrane Mass Spectrometer Interface for Continuous Measurement of Organic Compounds in Water", Anal. Chem., vol. 63, pp. 1335-1340 (1991).
Bauer et al., "Performance of an Ion Trap Mass Spectrometer Modified to Accept a Direct Insertion Membrane Probe in Analysis of Low Level Pollutants in Water", Talanta, vol. 40, pp. 1031-1039 (1993).
Stern et al., "Separation of Gas Mixtures in a Supersonic Jet. II. Behavior of Helium-Argon Mixtures and Evidence of Shock Separation", J. Chem. Phys., vol. 33, pp. 805-813 (1960).
Lauritsen et al., "Microporous Membrane Introduction Mass Spectrometry with Solvent Chemical Ionization and Glow Discharge for the Direct Detection of Volatile Organic Compounds in Aqueous Solution", Anal. Chim. Acta, vol. 266, pp. 1-12 (1992).
Lauritsen et al., "Direct Detection and Identification of Volatile Organic Compounds Dissolved in Organic Solvents by Reversed-Phase Membrane Introduction Tandem Mass Spectrometry", Anal. Chem., vol. 64, pp. 1205-1211 (1992).

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