Analogs of the antibiotic spectinomycin

Details Analogs of the antibiotic spectinomycin Analogs of the antibiotic spectinomycin

1983-10-18

1986-07-29

Love, Ethel G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D32304, C07D49300

Patent

active

046032126

ABSTRACT:
The present invention relates to novel compounds and processes. In particular, the invention relates to novel analogs of the aminocyclitol antibiotic spectinomycin. More particularly, it relates to novel processes for synthesizing analogs of spectinomycin; both known analogs and the novel analogs of the present invention. Additionally, the invention includes novel intermediates.
The novel analogs of spectinomycin disclosed herein are useful as antimicrobial agents.

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patent: 4351771 (1982-09-01), White
patent: 4361701 (1982-11-01), White
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Green, T. W., Protective Groups in Organic Synthesis, Wiley (1981).
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White et al., in "Synthesis and In Vitro Antibacterial Properties of Alkylspectinomycin Analogs", The Journal of Antibiotics, vol. XXXVI, No. 3, pp. 339-342, Mar., 1983.
March, Advanced Organic Chemistry: Reactions, Mechanisms and Structure, McGraw-Hill Book Company, pp. 626-636, 1968.
David et al., "Stereochimie de la Cycloaddition sur les Ethers Butadienyliques d'Alcools Chiraux. Derives en 4 et 6 de Glucosides Perbenzyles", Tetrahedron, vol. 34, pp. 299-304, 1978.
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