Analogs of macrophage stimulating protein

Details Analogs of macrophage stimulating protein Analogs of macrophage stimulating protein

1996-12-16

1999-09-07

Saunders, David

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

514 2, 514 12, A61K 3516, A61K 3819

Patent

active

059488921

ABSTRACT:
MSP analogs which have increased heterodimer formation and enhanced biological activity compared recombinant MSP are provided. The analogs are constructed by substituting unpaired cysteine residues which may interfere with interchain disulfide bonding. DNA sequences encoding MSP analogs, vectors and host cells for the expression of MSP analogs, and pharmaceutical compositions are also provided. The analogs may be used to treat conditions treatable by MSP such as gastrointestinal or hematopoietic disorders.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 5219991 (1993-06-01), Leonard et al.
patent: 5315000 (1994-05-01), Degen
patent: 5527685 (1996-06-01), Leonard et al.
Freizner Degen, SJ et al. Biochemistry. 30:9781-9791, Oct. 1991.
Han, S. et al., Biochemistry. 30:9768-9780, Oct. 1991.
Wang, MH et al. J. Biol. Chem. 269(5): 3436-3440, Feb. 4, 1994.
Carson, Histotechnology: A Self-Instructional Text American Society of Clinical Pathologist Press pp. 158-160 (1990).
Degen et al. Biochemistry 30, 9781-9791 (1991).
Donate et al., Protein Science 3, 2378-2394 (1994).
Falk et al., Am. J. Physiol. 266, G987-1003 (1994).
Gaboriaud et al., J. Mol. Biol. 259, 995-1010 (1996).
Leonard et al., Exp. Cell Res. 114, 117 (1978).
Leonard et al., Exp. Cell. Res. 102, 434 (1976).
Methods of Enzymology v. 185 (Goeddel, D.V. ed.) Academic Press (1990).
Remington's Pharmaceutical Sciences, 18th ed. A.R. Gennaro, ed. Mark, Easton, PA (1990).
Ronsin et al. Oncogene 8, 1195-1202 (1993).
Thery et al., Dev. Genetics 17, 90-101 (1995).
Wang et al., J. Biol. Chem. 269, 3436-3440 (1994).
Wang et al., Science 266, 117-119 (1994).
Whitehead et al., (In Vitro Cellular & Developmental Biology, 23, 436-442 (1987).
Yoshimura et al., J. Biol. Chem 268 15461-15468 (1993).
Zhang et al., J. Biol. Chem. 271, 3884-3890 (1996).
U.S. application No. 08/622,720, filed Oct. 20, 1992.

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