Analgesic pentapeptides

Details Analgesic pentapeptides Analgesic pentapeptides

1978-08-08

1981-07-14

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

042785960

ABSTRACT:
Pentapeptides of the formula: ##STR1## wherein R.sup.1 is hydrogen, methyl, ethyl, propyl, 2-methyl-2-pentenyl, 2-methyl-1-pentenyl, cyclopropylmethyl, or cyclobutylmethyl; R.sup.2, R.sup.3, and R.sup.4 are, independently, hydrogen or methyl; and X is --OH, --NH.sub.2, --NHC.sub.n H.sub.2n+1 where n is 1, 2, 3, or 4, --OR.sup.3, or CH.sub.2 OR.sup.3, where R.sup.3 is hydrogen or lower alkyl of from 1 to 4 carbon atoms; or a pharmaceutically acceptable salt thereof; have analgesic activity upon administration to warm-blooded animals.

REFERENCES:
patent: 4128541 (1978-12-01), Sarantakis
Coy et al., Biochem. and Biophys. Res. Commun. 73, 1976 632-637.
Life Science 21, (1977), 559-562.
British Journal of Pharmacology 59, 1977, pp. 455, 456.
Science 194, 330-332, 1976.
Opiates and Endogenous Opioid Peptides, 1976, 239-246; 87-94; 79-86.
Nature 262, 1976, 738-739.
Nature 258, 1975, 577-579.
Reprinted from Nature 260, No. 5552, pp. 625-626, 1976.

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