Anaesthetic composition containing a steroid of the 5.alpha.-pre

Details Anaesthetic composition containing a steroid of the 5.alpha.-pre Anaesthetic composition containing a steroid of the 5.alpha.-pre

1974-12-13

1976-04-20

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424243, 2602395, 260349, 2603974, 26023955R, C07J 7100

Patent

active

039520315

ABSTRACT:
This invention relates to steroids of the pregnane and 19-norpregnane series having anaesthetic properties and compositions containing them. More particularly the present invention relates to such steroids having a variety of substituents in the 2.beta.-position, a 3.alpha.-hydroxy group and a 5.alpha.-hydrogen atom and esters and 20-ketals thereof. At the 11-position of such steroids is preferably either two hydrogen atoms or an oxo group. The compounds according to the invention may conveniently be prepared by reaction of an appropriate 2.alpha.,3.alpha.-epoxy-pregnane or 19-norpregnane with a reagent which introduces the desired 2.beta.-substituent and various modifications of the compound produced are described to produce compounds within the scope of the invention. The present invention provides compositions containing certain steroids of the pregnane and 19-norpregnane series and such compositions generally may be administered intravenously to induce anaesthesia, the invention providing methods of inducing anaesthesia.

REFERENCES:
patent: 3822297 (1974-07-01), Phillipps et al.
patent: 3869451 (1975-03-01), Phillipps et al.

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