Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1986-12-11
1989-11-21
Brown, Johnnie R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 18, 435 21, 435803, 435810, 935 78, 536 27, 436800, 436805, 436808, C12Q 168, C12Q 142, C07H 2100
Patent
active
048822698
ABSTRACT:
An amplified hybridization assay is described in which a family of signal-generating secondary probes bind to a primary probe that hybridizes to the target sequence of interest. Thus, an enormously amplified signal is generated by the hybridization event. The assay can be used for a variety of laboratory and clinical purposes and is automatable.
REFERENCES:
patent: 4358535 (1986-11-01), Falkow et al.
patent: 4486539 (1984-12-01), Ranki et al.
patent: 4563419 (1986-01-01), Ranki et al.
patent: 4581333 (1986-04-01), Kovrilsky et al.
patent: 4617261 (1986-10-01), Sheldon, III et al.
patent: 4626501 (1986-12-01), Landes
patent: 4670380 (1987-06-01), Dattagupta
patent: 4699876 (1987-10-01), Libeskind
patent: 4716106 (1987-12-01), Chiswell
patent: 4751177 (1988-06-01), Stabinsky
patent: 4755458 (1988-07-01), Rabbani et al.
Dunn, A. R. et al., In Methods in Enzymology, 65, Part I (Grossman, L. et al., ed.), Academic Press, NY, 1980, pp. 468-478.
Rigby et al., 1977, J. Mol. Biol. 113:237-251.
Langer et al., 1981, PNAS, 78:6633-6637.
Melton et al., 1984, Nucl. Acids Res. 12:7035-7056.
Forster et al., 1985, Nucleic Acids Res. 13(3):745-761.
Dunn et al., 1977, Cell 12:23-36.
Ruyechen & Wetmur, 1975, Biochem. 14:5529-5534.
Sancar & Rupp, 1979, BBRC 90:123-129.
Schneider & Wetmur, 1982, Biochemistry 21:608-615.
Kochetkov et al., 1971, Tetahedran Lett., 1993-1996.
Barrio et al., 1972, BBRC, 46:597-604.
Lee & Wetmur, 1973, BBRC, 50:879-885.
Alwine et al., 1979, Methods Enz. 68:220-2420.
Thomas, 1980, Proc. Natl. Acad. Sci: 77(9):5201-5205.
Woodhead and Malcolm, Apr., 1984, Biochem. Soc. Trans 12:279-280.
Ranki et al., 1983, Gene 21:77-85.
Molden et al., 1985, Clin. Physiol. Biochem. 3:174-183.
Syvanen et al., 1985, Nuc. Acid. Res. 13(8):2789-2802.
Collins and Hunsaker, 1985, Anal. Biochem. 151:281-224.
Schneider Robert J.
Shenk Thomas E.
Brown Johnnie R.
Jay Jeremy M.
Princeton University
LandOfFree
Amplified hybridization assay does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Amplified hybridization assay, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Amplified hybridization assay will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1425752