Amphipathic oligonucleotides and polynucleotides having potent a

Details Amphipathic oligonucleotides and polynucleotides having potent a Amphipathic oligonucleotides and polynucleotides having potent a

1999-08-10

2000-10-10

Elliot, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 255, C07H 2100

Patent

active

061303240

ABSTRACT:
The present invention provides novel compositions that show potent antiviral activity against both DNA and RNA viruses. In particular, the present invention provides oligo- and polyribonucleotides with potent antiviral activity against HIV and HCMV. These compositions are thought to operate in a novel fashion at an early stage of viral infection, meeting the need for alternatives or synergistic therapies to the toxic treatments currently available. The present invention also discloses methods for synthesizing oligo- and polyribonucleotides showing antiviral activity.

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Tutonda et al., "The Role of Hydrophobic Versus Hydrophilic Base Character in the Anti-HIV Activity of Purine-Containing Polyribonucleotides", Nucleosides & Nucleotides (1996), pp. 173-182.
Chan et al., "Antiviral Properties of Polyinosinic Acids Containing Thio and Methyl Substitutions", J. gen. Virol. (1981), pp. 291-299.
Broom et al., "Unusual Single-Stranded Polyribonucleotides as Potent Anti-HIV Agents", Journal of Medicinal Chemistry (1995), pp. 3253-3257.
Tutonda et al., "Antiviral Oligo-And Polyribonucleotides Containing Selected Triazolo[2,3-a]Purines", J. Med. Chem (1998), pp. 4958-4964.
Buckheit et al., "PMTI, A Broadly Active Unusual Single-Stranded Polyribonucleotide, Inhibits Human Immunodeficiency Virus Replication By Multiple Mechanisms", Antiviral Chemistry & Chemotherapy (1999), pp. 23-32.
Amarnath et al., Polyribonucleotides Containing Thiopurines Synthesis and Properties of Poly(1-Methyl-6-Thioguanylic Acid), Biochimica et Biophysica Acta (1977), pp. 16-23.

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