Amorphous form of cefuroxime ester

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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544 22, A61K 31545, C07D50124

Patent

active

045621810

ABSTRACT:
There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.
Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.
Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.

REFERENCES:
patent: 4267320 (1981-05-01), Gregson et al.
patent: 4444686 (1984-04-01), Jasys
Sato et al, Chem. Pharm. Bull., 29(9), 2675-2682 (1981).
Masters et al, "Aseptic and Closed Cycle Spray Drying in Pharmaceutical/Biochemicals Manufacture", in Process Biochemistry, Jan./Feb., 1975.
Ripple, "Remingtons Pharmaceutical Sciences", Chap. 88, pp. 1535-1552.

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