Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-01-13
2010-10-26
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07820674
ABSTRACT:
The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
REFERENCES:
patent: 5594135 (1997-01-01), Geiwiz et al.
patent: 5665718 (1997-09-01), Godel et al.
patent: 6566311 (2003-05-01), Nalesnik
patent: 6852719 (2005-02-01), Liu et al.
patent: 6951946 (2005-10-01), Kolb et al.
patent: 7115652 (2006-10-01), Yang
patent: 2004/0132782 (2004-07-01), Yang et al.
patent: WO 2005/103020 (2005-11-01), None
patent: WO 2005/103043 (2005-11-01), None
patent: WO 2006/057945 (2006-06-01), None
patent: WO 2006/078577 (2006-07-01), None
Barrett, D. G., Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K. Bio. Med. Chem. Lett., February 2004, vol. 14, pp. 2543-2546.
Han, Y. Novel pyrazinone mono-amides as potent and reversible caspase-2 inhibitors. Bio. Med. Chem. Lett. December 2004, vol. 15, pp. 1173-1180.
Coburn Craig A.
Nantermet Philippe G.
Rajapakse Hemaka A.
Selnick Harold G.
Stauffer Shaun R.
Anderson Rebecca L
MacMillan Keith D.
Merck Sharp & Dohme Corp.
Nolan Jason M
Todaro John C.
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