Aminomethyl beta-secretase inhibitors for the treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

07820674

ABSTRACT:
The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

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Barrett, D. G., Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K. Bio. Med. Chem. Lett., February 2004, vol. 14, pp. 2543-2546.
Han, Y. Novel pyrazinone mono-amides as potent and reversible caspase-2 inhibitors. Bio. Med. Chem. Lett. December 2004, vol. 15, pp. 1173-1180.

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