Amino-derivatized phosphite and phosphate linking agents, phosph

Details Amino-derivatized phosphite and phosphate linking agents, phosph Amino-derivatized phosphite and phosphate linking agents, phosph

1985-08-26

1988-07-12

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, 536112, 536117, C07H 1906, C07H 1910, C07H 1916, C07H 1920

Patent

active

047571411

ABSTRACT:
The compounds of the invention include novel linking agents comprising 2-substituted-3-protected-1,3,2-oxazaphosphacycloalkanes and their phosphoramidite precursors. The compounds of the invention further include conjugates of the above linking agents with oligonucleotides and polymer supports. The compounds of the present invention are useful for linking organic moieties, such as fluorescent or chromogenic dyes, to polymer supports and oligonucleotides, particularly single- and double-stranded DNA and RNA fragments.

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2-Substituted N-phenyl- and N-benzyl-1,3,2-oxaazaphospholanes; Pudovik, M. A.; Pudovik, A. N.; Shulyndina, O. S.; Nagaeva, Kh. Kh., Chemical Abstracts, vol. 74, No. 23, Jun. 7, 1971, pp. 466-467.
Synthesis of some Nucleoside Cyclic Phosphoramidates and Related Compounds via Phosphoramidites, A. Stanley Jones, Christopher McGuigan, and Richard T. Walker, J. Chem. Soc. Perkin Trans. I 1985, pp. 199-202.

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