Amino acid derivatives with renin-inhibiting properties, a proce

Details Amino acid derivatives with renin-inhibiting properties, a proce Amino acid derivatives with renin-inhibiting properties, a proce

1990-09-10

1994-12-20

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40112, A61K 31455, A61K 31445

Patent

active

053747313

ABSTRACT:
Amino acid derivatives with renin-inhibiting properties, a process for the preparation thereof, agents containing these, and the use thereof
The invention relates to renin-inhibiting amino acid derivatives of the formula ##STR1## in which R.sup.1 is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO.sub.2 or SO, Y is CH.sub.2, O or S, B is the radical of an amino acid of the formula H--B--OH, and R.sup.3, R.sup.4 and R.sup.5 are as defined in the description, a process for the preparation thereof, agents containing these, and the use thereof.

REFERENCES:
patent: 4855286 (1989-08-01), Wagner et al.
patent: 5055466 (1991-10-01), Weller, III et al.
patent: 5116835 (1992-05-01), Ruger et al.

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