Amino acid derivatives, processes for the manufacture thereof an

Details Amino acid derivatives, processes for the manufacture thereof an Amino acid derivatives, processes for the manufacture thereof an

1998-07-08

2000-11-14

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544374, C07D40312

Patent

active

061472123

ABSTRACT:
The invention relates to new amino acid derivatives of general formula I and the pharmaceutically acceptable salts thereof, wherein group B is --A.sup.2 --NR.sup.2 R.sup.3 or R.sup.5, wherein group R.sup.5 is ##STR1## and R.sup.1, A.sup.1, A.sup.2, R.sup.2, R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X, Y, Z, t and u have the meanings described in the specification, as well as the preparation and use thereof. The novel compounds are valuable neurokinin (tachykinin) antagonists.

REFERENCES:
patent: 5321032 (1994-06-01), Masaaki et al.
patent: 5596000 (1997-01-01), Esser et al.
patent: 5700827 (1997-12-01), Schnorrenberg et al.

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