Amino acid derivatives of chloromethylated polymers and methods

Chemistry of carbon compounds – Miscellaneous organic carbon compounds

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260 22R, 260 78A, 526 17, 526 42, C08F 800, C08F 832

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active

039692841

ABSTRACT:
The application discloses polymers and methods of making same in which a chlorine atom of a chloromethyl pendant group of a polymer such as a chloromethylated copolymer of styrene and divinylbenzene is substituted with a derivative of malonic acid having a protected amino group on the alpha-carbon atom and two carboxyl groups or precursors thereof to form, via several steps, the alpha-amino acid derivative of the starting polymer. These polymers are used, for instance, as ion exchange resins, as substrates for affinity chromotography, and as a starting resin for solid peptide synthesis. The resultant polymer is also used as a starting material to make a polymer with a pendant group that is a derivative of oxazolidone-2,5-dione, substituted at the 4-position. These polymers are used, for example, as the matrix for solid phase peptide synthesis and as the starting resin for solid phase peptide degradation.

REFERENCES:
Journal of the American Chemical Society, vol. 67 (1945) pp. 502-503.
Flory- principles of Polymer Chemistry, 1953, pp. 75- 78, 102-103.

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