Amino acid analog CCK antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546169, 546201, 546229, 546156, 540467, 540470, 544333, 544373, 544386, 5483381, 5483385, 514 19, A61K 3147, C07D21522, C07D20918

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053469070

ABSTRACT:
Analogs of CCK-tetrapeptides, which analogs have the formula ##STR1## wherein A, B, D, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are specifically defined, having activity as CCK antagonists, useful in the treatment or prevention of disorders of the gastrointestinal, central nervous, appetite regulating or pain regulating systems.

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Bohnert, et al. Z. Naturforsch 426, 1159-1166 1987.
Schroff, J. Med. Chem. 1982 25 359-362.
Jensen, et al. Biochemica et Biophys Acta 757 (1983) 250-258.
Bock, et al. J. Med. Chem. 1989, 32, 13-16.
Faris, et al. Science, vol. 226, 1984 pp. 1215-1217.
Hahne, Proc. Natl. Acad. Sci. USA 78(10) pp. 6304-6308, 1981.

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