Amine salt of carbostyril derivative

Details Amine salt of carbostyril derivative Amine salt of carbostyril derivative

2005-01-20

2010-06-08

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S312000

Reexamination Certificate

active

07732611

ABSTRACT:
The invention provides an amine salt of a carbostyril derivative formed from a carbostyril derivative represented by the formula (1) [wherein R is a halogen atom; the substituted position of the side chain is 3- or 4-position in the carbostyril skeleton; and the bonding between 3- and 4-positions of the carbostyril skeleton is a single bond or a double H bond] and an amine; and the invention is useful as drugs for treating various diseases, especially as aqueous formulations due to the superior water solubility and the superior pharmacologic effects.

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Abstract of M. Uchida et al., “Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. Synthesis and anticulcer activities of optically active .alpha.-amino acid derivatives of 2(1H)-quinolinone and oxindole,” Chemical and Pharmaceutical Bulletin, vol. 35, No. 2, 1987, pp. 853-856.
C. G. Wermuth (ED), Bradley D. Anderson & Karl P. Flora, The Practice of Medical Chemistry, Sep. 25, 1999, pp. 347-365.

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