Amidine derivatives and platelet aggregation inhibitor containin

Details Amidine derivatives and platelet aggregation inhibitor containin Amidine derivatives and platelet aggregation inhibitor containin

1996-08-19

1998-02-17

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142282, 5142335, 514444, 514457, 514337, 514256, 514253, 514320, 544151, 544 62, 5462827, 549 60, 549404, 549405, A61K 3154, A61K 31535, C07D31104, C07D31176

Patent

active

057191450

ABSTRACT:
The invention relates to a substituted amidine derivative which has an excellent platelet aggregation inhibiting action on the basis of fibrinogen antagonism and is particularly excellent in effectiveness on oral administration, and the platelet aggregation inhibitor containing the substituted amidine derivative of the invention as an effective ingredient is effective for prevention and treatment of thrombosis, and restenosis or reocclusion after percutaneous transluminal coronary angioplasty or percutaneous transluminal coronary recanalization.

REFERENCES:
Cook et al, "Platelet Clycoprotein IIB/IIIa Antagonists", Drugs of the Future, 19(2), pp. 135-159, 1994.
Weller et al, "Fibrinogen Receptor Antagonists--A Novel Class of Promising Antithrombotics", Drugs of the Future, 19(5), pp. 461-476, 1994.
D. Huckle et al, "3-Amino-4-Chromanone Hydrochlorides", J. Med. Chem., 12, pp. 277-279, 1969.

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