Amidine compound, process for producing same and anti-complement

Details Amidine compound, process for producing same and anti-complement Amidine compound, process for producing same and anti-complement

1984-05-21

1985-04-30

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 35, 562440, 549436, 564247, 260465D, 560 1, 560 9, 560 12, 560 18, 560 20, 560 32, 560 34, 560 37, 560 48, 560 49, 560 51, 560 55, 560 66, 560 72, 560 75, 560 81, 560 86, 560104, 560105, 560107, 560109, 560115, 560122, 560123, 560124, 560125, 560128, 560140, 560142, 560 61, C07C11900, A61K 3122, A61K 31235

Patent

active

045144168

ABSTRACT:
Amidino compounds represented by the formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II)

REFERENCES:
patent: 4454338 (1984-06-01), Fujii
Fujii, Biochim. Biophys. Acta, 661, pp. 342-345 (10/31/81).

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