Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-05-15
2007-05-15
McKane, Joseph K. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S235500, C514S427000, C544S060000, C544S133000, C546S246000, C546S268100, C548S561000, C548S566000
Reexamination Certificate
active
10258959
ABSTRACT:
N-(2-aminoaryl-propionyl)-amides of formula (1) are described.The process for their preparation and pharmaceutical preparations thereof are also described.The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of 2-(aminoaryl)-propionyl amides of formula (1) for use in the ihibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.
REFERENCES:
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Endo et al., Tetrahedron Letters, 1997, 58(12): 2113-2116.
Singhvi et al., 1997, CAS: 127:140326.
Hicks et al., 1979, CAS:91:204211.
Ostermayer et al., 1971, CAS: 75:48900.
Borck et al., 1970, CAS:73:25138.
Allegretti Marcello
Bertini Riccardo
Bizzarri Cinzia
Caselli Ginfranco
Cesta Maria Candida
Dompe S.p.A.
McKane Joseph K.
Shiao Rei-tsang
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