Amide compounds and medications containing the same

Details Amide compounds and medications containing the same Amide compounds and medications containing the same

2008-07-01

2008-07-01

Morris, Patricia L (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S270100

Reexamination Certificate

active

10985938

ABSTRACT:
The present invention provides to a novel compound having an ACAT inhibiting activity.The present invention relates to compounds represented by formula (I)wherein represents an optionally substituted divalent residue such as benzene, pyridine, cyclohexane or naphthalene, or a group,Het represents a 5- to 8-membered, substituted or unsubstituted heterocyclic group containing at least one heteroatom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, such as a monocyclic group, a polycyclic group or a group of a fused ring,X represents —NH—, an oxygen atom or a sulfur atom,Y represents —NR4—, an oxygen atom, a sulfur atom, a sulfoxide or a sulfone,Z represents a single bond or —NR5—,R4represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group,R5represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, andn is an integer of from 1 to 15,or salts or solvates thereof, and a pharmaceutical composition containing at least one of these compounds.

REFERENCES:
patent: 5290801 (1994-03-01), Higley et al.
patent: 5358946 (1994-10-01), Wilde
patent: 0 807 627 (1997-11-01), None
patent: 4-139172 (1992-05-01), None
El-Ezbawy et al., “Synthesis and antibacterial activity, etc.,” CA 113:78227 (1990).
Abdel et al., “Synthesis and Biological Activities of Some New 2-(N-Heterocyclo Carboxamidomethyl Thio) Naphth[1,2-d]Oxazoles. Part VI,” J. Indian Chem. Soc. LVIII:171-173 (1981).
Bellemin et al., “New Indole Derivatives as ACAT Inhibitors: Synthesis and Structure-Activity Relationships,” Eur. J. Med. Chem. 31:123-132 (1996).
Brandstrom et al., “Structure activity relationships of substituted benzimidazoles,” Scand. J. Gastroenterol., 20(Suppl. 108)15-22 (1985).
Lindberg et al., “The Mechanisms of Action of the Gastric Acid Secretion Inhibitor Omeprazole,” Journal of Medicinal Chemistry 29(8):1327-1329 (1986).
Mahmoud et al., “Synthesis and biological activities of some new 2-(N-heterocyclic carboxamidomethyl thio) benzoxazoles, benzthiazoles and benzimidazoles. Part VIII,” Eur. J. Med. Chem. 16(4):383-384 (1981).
Mahmoud et al., “Synthesis of Some New Aryl-and Aralkyl-Mercaptobenzoxazoles,- Benzimidazoles and -Benzothioazoles of Potential Biological Interest,” Gazetta Chimica Italiana 112:55-56 (1982).
Matsuda et al., “ACAT Inhibitors as Antiatherosclerotic Agents: Compounds and Mechanisms,” Medicinal Research Reviews 14(3):271-305 (1994).
Wilde et al., “ACYL CoA:Cholesterol Acyltransferase (ACAT) Inhibitors: Ureas Bearing Heterocyclic Groups Bioisosteric for an Imidazole,” Biorganic & Medicinal Chemistry Letters 5(2):167-172 (1995).
Wilde et al., “ACYL CoA:Cholesterol Acyltransferase (ACAT) Inhibitors: Ureas Bearing Two Heterocyclic Head Groups,” Biorganic & Medicinal Chemistry Letters 5(2):173-176 (1995).

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