Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2006-07-04
2006-07-04
Minnifield, N. M. (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S324000, C530S325000, C530S326000, C530S327000, C514S012200
Reexamination Certificate
active
07071293
ABSTRACT:
The present invention relates to the use of antimicrobial peptides in the inhibition of microbial growth and proliferation. Novel antimicrobial truncated peptides are disclosed which are based upon SMAP 29 and RCAP 18, but which contain a lesser number of amino acid residues yet still retain bactericidal activity. In addition, synthetic peptides based upon the SMAP 29 protein are disclosed which have fewer amino acid residues and include substitutions yet retain substantial activity. The invention also relates to a method of inhibiting microbial growth by administering an effective amount of a peptide in accordance with the invention, or by combining the peptides with other antimicrobial agents or antibiotics.
REFERENCES:
patent: 5618675 (1997-04-01), Larrick et al.
patent: 6103888 (2000-08-01), Larrick et al.
patent: 6492328 (2002-12-01), Lehrer et al.
patent: 6809181 (2004-10-01), McCray et al.
patent: 2002/0082195 (2002-06-01), Lehrer et al.
patent: 2003/0022829 (2003-01-01), Maury et al.
patent: 2003/0054422 (2003-03-01), Badley et al.
patent: 2003/0143234 (2003-07-01), Shi et al.
patent: 2004/0086535 (2004-05-01), Maury et al.
patent: 2004/0137482 (2004-07-01), Eckert et al.
patent: 2005/0124064 (2005-06-01), Schnorr et al.
patent: 2005/0239709 (2005-10-01), Hogenhaug
patent: 2005/0250699 (2005-11-01), Hogenhaug et al.
patent: 2005/0277176 (2005-12-01), McCray et al.
patent: 1359930 (2004-09-01), None
patent: WO 94/02589 (1994-02-01), None
Turner et al.,Antimicrobial and Chemotherapy vol. 42, No. 9, pp. 2206-2214, 1998..
Tossi et al. , FEBS Letters vol. 339, pp. 108-112, 1994..
Merluzzi et al.,Peptides, vol. 261, pp. 639-640, 1996.
Bagella et al., FEBS Letters, vol. 376, pp. 225-228, 1995.
Mahoney et al., FEBS Letters, vol. 377, pp. 519-522, 1995.
Sequence alignments for SEQ ID No. 27.
Sequence Alignment # AAR45671.
Larrick et al. Infection and Immunity, vol. 63, No. 4, pp. 1291-1297, 1995.
Sequence alignment Accession No. JQ1171.
Bagella et al., “cDNA sequences of three sheep myeloid cathelicidins,”FEBS Lett., 376:225-228, 1995.
Boman, “Peptide antibiotics and their role in innate immunity,”Annu. Rev. Immunol., 13:61-92, 1995.
Gallo et al., “Antimicrobial peptides: an emerging concept in cutaneous biology,”J Invest Dermatol., 111(5):739-43, 1998.
Ganz and Lehrer, “Antimicrobial peptides of vertebrates,”Current Opinions Immun,. 10:41-44, 1998.
Gennaro and Zanetti, “Structural features and biological activities of the cathelicidin-derived antimicrobial peptides,”Bipoly, 55:31-49, 2000.
Hirata, et al., “Characterization of a rabbit cationic protein (CAP18) with lipopolysaccharide-inhibitory activity,”Infect. Immun. 62 (4), 1421-1426 (1994).
Hwang et al., “Structure-function relationships of antimicrobial peptides,”Biochem Cell Biol, 76(2-3):235-46, 1998.
Mahoney et al., “Molecular analysis of the sheep cathelin family reveals a novel antimicrobial peptide,”FEBS Lett, 377:519-522, 1995.
Oren et al., “Mode of action of linear amphipathic α-helical antimicrobial peptides,”Biopolymers, 47(6):451-63, 1998.
Russell et al., “Coordinate induction fo two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha,”Infect Immun, 64(5):1565-8, 1996.
Skerlavaj et al., “SMAP-29: a potent antibacterial and antifungal peptide from sheep leukocytes,”FEBS Letters, 463:58-62, 1999.
Bals et al., “The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface,”Proc. Natl., Acad. Sci. USA, 95:9541-9546, 1998.
Huttner et al., “Localization and genomic organization of sheep antimicrobial peptide genes,”Gene, 206:85-91, 1998.
Merluzzi et al., “Biological Activity of a navel, cathelicidin-derived antimicrobial peptide from sheep,”Peptides, 261:639-640, 1996.
Tossi et al., “Design of synthetic antimicrobial peptides based on sequence analogy and amphipathicity,”Eur. J. Biochem., 250:549-558, 1997.
Tossi et al., “Identification and characterization of a primary antibacterial domain in CAP 18, a lipopolysaccharide binding protein from rabbit leukocytes,”FEBS Letters, 339:108-112, 1994.
Travis et al., “Bactericidal activity of mammalian cathelicidin-derived peptides,”Infection and Immunity, 68:2748-2755, 2000.
Lehrer Robert
McCray, Jr. Paul B.
Tack Brian F.
Travis Sue M.
Welsh Michael
Fulbright & Jaworski
Minnifield N. M.
The Regents of the University of California
The University of Iowa Research Foundation
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