Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-07-01
1979-02-13
Douglas, Winston A.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260558A, 260558S, 260559T, 260559A, 260561R, 260561A, 260561S, 260561N, 260564A, 1605705S, 260583FF, 536 26, 560 24, 560 33, 560157, 560159, 560165, 424244, 424300, 424316, 424320, 424325, 424330, C07C 8724, C07C 6902, C07C10310, C01B 2526
Patent
active
041395638
ABSTRACT:
Novel acetylenic derivatives of amines of the following general structure: ##STR1## WHEREIN Z is .beta.-methylthioethyl, .beta.-benzylthioethyl, S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, .gamma.-guanidinopropyl, or ##STR2## WHEREIN N IS 2 OR 3 AND R.sub.1 is hydrogen or lower alkyl of from 1 to 4 carbon atoms with the proviso that when R.sub.1 is other than hydrogen, n is 2; and each of R.sub.a and R.sub.b is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or ##STR3## wherein R.sub.2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or .rho.-hydroxybenzyl; with the provisos that when Z is .beta.-benzylthioethyl or S-(5'-desoxyadenosin-5'-yl)-S-methylthioethyl, R.sub.b is hydrogen, and when Z is ##STR4## EACH OF R.sub.a and R.sub.b can be the same or different; and pharmaceutically acceptable salts and individual optical isomers thereof.
REFERENCES:
patent: 3024190 (1962-03-01), Bennett et al.
patent: 3160664 (1964-12-01), Dawson
patent: 3291683 (1966-12-01), Lamb
patent: 3320277 (1967-05-01), Mehta et al.
patent: 3538228 (1970-11-01), Nair
patent: 3960927 (1976-06-01), Metcalf et al.
Mavrov et al., "Index Chemicus", vol. 30, #93265 (1968).
SIFA, "French Patents Abstracts", vol. 6, No. 47, p. 3:7 (1966).
Dumont et al., "Chem. Ab.", Ab. No. 66:115254r (1967).
Jung Michel
Metcalf Brian W.
Doll John
Douglas Winston A.
Hattan L. Ruth
Merrell Toraude et Compagnie
Rauchfuss, Jr. George W.
LandOfFree
.alpha.-ACETYLENIC DERIVATIVES OF AMINES does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with .alpha.-ACETYLENIC DERIVATIVES OF AMINES, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and .alpha.-ACETYLENIC DERIVATIVES OF AMINES will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-691137