Alkynyl compounds as non nucleoside reverse transcriptase...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S358000, C514S473000, C514S563000, C514S621000, C546S309000, C546S337000, C549S475000, C558S411000, C562S433000, C564S169000

Reexamination Certificate

active

11238732

ABSTRACT:
Inhibitors of HIV reverse transcriptase which are useful for the treatment of HIV infection. Exemplars of the invention are compounds of the formulawherein the substituents are as defined in the following tableR1R2R4R5R8aFCF3MeH—OHFCF3ClH—OHFCF3MeH—O—CH2CO2HClCNClH—OH.

REFERENCES:
patent: 2439820 (2002-09-01), None
patent: WO 01/17982 (2001-03-01), None
patent: 02070470 (2002-09-01), None
patent: 2004050643 (2004-06-01), None
Wyatt et al, Journal of Medicinal Chemistry, vol. 38, pp. 1657-1665, 1995.
Chan, et al; Novel Benzophenones as Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1; Journal of Medicinal Chemistry; 2004; vol. 47; pp. 1175-1182.
International Preliminary Report on Patentability for PCT/CA2005/001480.

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