Alkanoarachidonic acids

Details Alkanoarachidonic acids Alkanoarachidonic acids

1984-09-27

1988-07-26

Evans, J. E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2604109R, 514531, 514559, 514729, 514703, 568420, 568700, C11C 100, C07C 3305, C07C 4721, A61K 31045

Patent

active

047598808

ABSTRACT:
A series of alkanoarachidonic acids have been prepared as modulators of the arachidonic acid cascade to increase the production of biologically desirable compounds and minimize the production of biologically undesirable compounds. Examples of desirable compounds in this respect comprise postaglandins and thromboxanes whereas undesirable compounds comprise the mono- and polyhydroxyarachidonic acids and leukotrienes. The alkanoarachidonic acids and their intermediates are of the general formula: ##STR1## and at least one of X, Y, and Z is lower alkano and is hydrogen when not lower alkano; the esters and salts of the acids are also prepared. The acids, esters and salts may be used as anti-anaphylaxis or anti-thrombosis agents.

REFERENCES:
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patent: 4464304 (1984-08-01), Porter et al.
patent: 4515727 (1985-05-01), Patterson, Jr. et al.
patent: 4599439 (1986-07-01), Misra

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