Aliphatic amino carboxylic and amino phosphonic acids amino...

Details Aliphatic amino carboxylic and amino phosphonic acids amino... Aliphatic amino carboxylic and amino phosphonic acids amino...

2006-01-10

2006-01-10

Desai, Rita (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C514S114000

Reexamination Certificate

active

06984754

ABSTRACT:
Novel compounds of formula (I) are described wherein: R1=(CH2)mCH3where m is 0 or an integer in the range from 1 to 16, or an alkenyl, alkynyl, alkoxy, alkylthio, or alkyl sulfinyl group having from 2 to 17 carbon atoms; R2=H, CH3or CH2CH3; R3=H or CH3; R4H or CH3; R5=lower alkyl having from 1 to 5 carbon atoms; n is an integer in the range from 1 to 3, and X is carboxyl (COOH) or carbalkoxy (COOR5), cyano (C≡N), phosphonic acid (PO3H2), phosphonate ester (PO3[R5]2) or 5-tetrazole, and pharmaceutically acceptable salts thereof. Preferably, the compounds are optically pure enantiomers of the R— or S—configuration in which R3=R4=R5=H, R2=CH3and R1is a saturated aliphatic chain of one to five carbon atoms. The compounds are useful as cellular rescue agents

REFERENCES:
patent: 3991208 (1976-11-01), Dudzinski et al.
patent: 4548726 (1985-10-01), Morris-Sherwood et al.
patent: 4804500 (1989-02-01), Miller et al.
patent: 4961873 (1990-10-01), Ho et al.
patent: 5565290 (1996-10-01), Itakura et al.
patent: 5723239 (1998-03-01), Itakura et al.
patent: 11 39 738 (1962-11-01), None
patent: 15 67 221 (1970-04-01), None
patent: 20 52 256 (1971-05-01), None
patent: 24 42 239 (1975-03-01), None
patent: 25 55 769 (1977-06-01), None
patent: 2 451 913 (1980-10-01), None
patent: WO 92/15551 (1992-09-01), None
patent: WO 96/05286 (1996-02-01), None
patent: WO 97/45115 (1997-12-01), None
Tien et al, JACS, 1955, vol. 77 pp. 6696-6698.
CA 1998:45464: Hamper et al, Journal of Organic Chemistry, vol. 63 (3) (1998) pp. 708-718.
CA 1996:637648.
CA 1995:878827, WO 9512610.
CA 1993:46312, Nakamura et al, Colloids and Surfaces (1992) vol. 67, pp. 183-193.
CA 1992:59021, Bulletin of the Korean Chemical Society, 1991, vol. 12(5) p. 589.
CA 1991:27105 CA 1989:38631, ES patent 2003836.
CA 1987:440328.
Nishimura, Kuniko et al. “Inactivation of Monoamine Oxidase B by Analogues of the Anticonvulsant Agent Milacemide (2-(n-Pentylamino) acetamide)”, Journal of Medicinal Chemistry, vol. 36, No. 4, pp. 446-448, 1993.
Satzinger, Gerhard. “5-Substituted and 1,5-condensed tetrazoles”, Chemical Abstracts, vol. 55, No. 15, p. 14441, 1961.
Leonard, Frederick et al. “Potential Antiviral Agents”, Journal of the American Chemical Society, vol. 78, No. 6, pp. 1199-1201, 1956.
Boit, Hans-G. Beilsteins Handbuch Der Organischen Chemie, 4th Ed., 3rd Suppl.,vol. 4, Part 2, p. 1137, 1963.
Luckenbach, Reiner. “Beilsteins Handbuch Der Organischen Chemie”. 4th Ed., 4th Suppl., vol. 4, Part 3, p. 2386, 1980.
Miyagishi, Shigeyoshi et al. “Phase Transition of N-Acyl Amino Acids with Different Acyl Group”, Bulletin of the Chemical Society of Japan, vol. 59, No. 2, pp. 557-562, 1986.
Kirino, Osamu et al.“Studies on anti-fusarium disease activity of aminonitrile derivatives . . . ”,Chemical Abstracts,vol. 92, No. 23, p. 167, 1980.
Corse, Joseph et al. “N-Substituted 2-Methoxy-6-chloro-9-aminoacridines Derived from Unsymmetrical Aliphatic Amines”, Journal of the American Chemical Society, vol. 68, pp. 1905-1910, 1946.
Ishizuka, Tetsuo et al. “Alkyl-beta-amines from long-chain olefins”, Chemical Abstracts, vol. 74, No. 8, p. 70, 1971.
Sakakibara, Seizaburo et al. “Cationic surface-active agents from long-chain alkyl amines and acrylonitrile”, Chemical Abstracts, vol. 55, No. 8, p. 7275, 1961.
Takahashi, Hisashi, “Effects of derivatives of gamma-amniobutyric acid . . . ”, Chemical Abstracts, vol. 55, No. 23, p. 23837, 1961.

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