Aliphatic amino bis-aryl squalene synthase inhibitors

Details Aliphatic amino bis-aryl squalene synthase inhibitors Aliphatic amino bis-aryl squalene synthase inhibitors

1995-01-25

1996-07-09

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548152, 548178, 548179, A61K 31425, C07D27764, C07D27766

Patent

active

055345328

ABSTRACT:
This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

REFERENCES:
Fujita et al., Chem. Pharm. Bull., 38(4), 936-941 (1990).

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