Alginate hydrogel foam wound dressing

Details Alginate hydrogel foam wound dressing Alginate hydrogel foam wound dressing

1989-01-24

1990-08-14

Green, Randall L.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Gas produced in situ by chemical reaction

424445, 424DIG13, 424 43, 128156, A61L 1542, A61L 2500

Patent

active

049485750

ABSTRACT:
A dimensionally stable alginate hydrogel foam wound dressing that absorbs wound exudate without any appreciable swelling. The wound dressing is formed-in-place in the wound cavity or on the wound surface from a reactive composition that foams as it gels. The water-insoluble alginate hydrogel foam based wound dressing is made by mixing together the ingredients of a two component system; applying the resulting composite liquid mixture to a wound site; and allowing the composite mixture to react. One component contains an aqueous suspension of certain di-or trivalent metal salts and an effervescent compound. The second component contains an aqueous solution of a biocompatible, water-soluble acid. At least one compound, and preferably both, contain a water soluble alginate.

REFERENCES:
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patent: 4391799 (1983-07-01), Mason, Jr. et al.
patent: 4393048 (1983-07-01), Mason, Jr. et al.
patent: 4401456 (1983-08-01), Connick, Jr.
patent: 4613497 (1986-09-01), Chavkin
patent: 4704113 (1987-11-01), Schoots
Davis et al., "In Vitro Evaluation of Alginate Gel Systems as Sustained Release Drug Delivery Systems", J. of Controlled Release, vol. 3, (1986), pp. 167-175.

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