Aldolases, nucleic acids encoding them and methods for...

Details Aldolases, nucleic acids encoding them and methods for... Aldolases, nucleic acids encoding them and methods for...

2003-08-19

2008-08-19

Nashed, Nashaat T. (Department: 1656)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S053000, C435S069100, C435S069700, C435S232000, C435S252300, C435S320100, C536S023400

Reexamination Certificate

active

07414119

ABSTRACT:
The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.

REFERENCES:
patent: 5256800 (1993-10-01), Kaneko
patent: 5292891 (1994-03-01), Kaneko
patent: 5457227 (1995-10-01), Thottathil
patent: 5795749 (1998-08-01), Wong
patent: 5998633 (1999-12-01), Jacks et al.
patent: 6033883 (2000-03-01), Barr et al.
patent: 7026121 (2006-04-01), Wohlgemuth et al.
patent: 2003/0053950 (2003-03-01), Leyland-Jones
patent: 2003/0158426 (2003-08-01), Kooistra
patent: 2003/0229044 (2003-12-01), Steinman et al.
patent: 2003/0232416 (2003-12-01), Wong et al.
patent: WO-02/06266 (2002-01-01), None
patent: WO-03/006656 (2003-01-01), None
Kawarabayasi, Y., et al., 1999, “Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon, Aeropyrum pernix K1.”, DNA Research, vol. 6, No. 1, pp. 83-101.
UniProt Accession No. DEOC—AERPE, 2000, (Kawarabayasi, Y., et al.) “Probable deoxyribose-phosphate aldolase (EC 4.1.2.4)”, 235 AA; 24529 MW.
Barbas III et al., PNAS USA (1991) 88:7978-7982.
Bennett et al., J. Chem. Soc. Perkin Trans. (1991) 1:133-140.
Brinkkotter et al., Arch. Microbiol. (2002) 177:410-419.
Brower et al., Tetrahedron Letters (1992) 33(17):2279-2282.
Chappel et al., J. Inher. Metab. Dis. (1983) 6:105-107.
Desantis et al., Bioorganic and Medicinal Chemistry (2003) 11:43-52.
Evans et al., Top. Stereochem. (1982) 13:1-115.
Evans, Science (1988) 240:420-426.
Fessner and Helaine, Current Opinion in Biotechnology (2001) 12:574-586.
Fong et al., Chemistry and Biology (2000) 7:873-883.
Gefflaut et al., Prog. Biophys. Molec. Biol. (1995) 63:301-340.
Gijsen and Wong, J. Am. Chem. Soc. (1995) 117:7585-7591.
Gijsen and Wong, J. Am. Chem. Soc. (1994) 116:8422-8423.
Heathcock, Aldrichim. Acta (1990) 23:99-111.
Heathcock et al., in Comprehensive Organic Synthesis, vol. 2, B.M. Trost, ed., Pergamon, Oxford, (1991) pp. 133-319.
Heathcock, Science (1981) 214:395-400.
Hoffee, Archives of Biochemistry and Biophysics (1968) 126:795-802.
Janda et al., PNAS USA (1994) 191:2532-2536.
Jargiello et al., Archives of Biochemistry and Biophysics (1976) 177:630-641.
Lai et al., Science (1974) 183:1204-1206.
Liu and Wong, Angew. Chem. Int. Ed. (2002) 41:1404-1407.
Margolin, Enzyme Microb. Technol. (1993) 15:266-280.
Masamune et al., Angew. Chem. Int. Ed. Engl. (1985) 24:1-30.
Mc Cague et al., Tetrahedron Letters (1993) 34:3785-3786.
Morris and Tolan, Biochemistry (1994) 33:12291-12297.
Patel, Current Opinion in Biotechnology (2001) 12:587-604.
Paterson, Pure & Applied. Chem. (1992) 64:1821-1830.
Rosen and Heathcock, Tetrahedron (1986) 42:4909-4951.
Rosen et al., J. Org. Chem. (1984) 49:3657-3659.
Rosen et al., J. Org. Chem. (1984) 49:3994-4003.
Saaby et al., J. Org. Chem. (2002) 67:4352-4361.
Sakaki et al., Tetrahedron: Asymmetry (1991) 2(5):343-346.
Schmid et al., Current Opinion in Biotechnology (2002) 13:359-366.
Takayama et al., Annu. Rev. Microbiol. (1997) 51:285-310.
Wong et al., J. Am. Chem. Soc. (1995) 117:3333-3339.
Wong, Science (1989) 244:1145-1152.
Wymer and Toone, Current Opinion in Chemical Biology (2000) 4:110-119.
International Search Report for PCT/US03/27334, mailed on Aug. 28, 2007, 5 pages.
Deckert et al., Nature (1988) 392:353-358, Accession AE000657.1 and peptide GI No. 2982875.

Affiliated with

Also associated with

Rating

Aldolases, nucleic acids encoding them and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aldolases, nucleic acids encoding them and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aldolases, nucleic acids encoding them and methods for... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4011496