Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-09-30
1990-12-04
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424 88, 514800, 530313, 530328, A61K 3738
Patent
active
049754203
ABSTRACT:
A technique has been developed to cause a mammal to generate antibodies which will bind to its native GnRH thus suppressing the mammal's fertility. The technique involves vaccinating a mammal with a novel conjugate of an immuno stimulating carrier and a novel GnRH analogue. The analogue is substantially identical to the natural GnRH which is common to all mammals except that one or more of the normally occurring amino acids of this decapeptide have been replaced by an amino acid with a more reactive side group. A favored technique is to utilize an analogue containing cysteine which, of course, has as a sulfhydryl side group. This analogue may then be conjugated to a large protein carrier using a heterobifunctional agent carrying a group reactive with carboxyl or amino groups and a group reactive with sulfhydryl groups. This conjugate then forms the immunogen base for a vaccine which may also contain art recognized adjuvants. The vaccine formulation is then administered in a manner which raises a substantial amount of antibodies which bind to native GnRH. Injection in a manner which provides a slow release to the circulatory system such as IP, IM or SC is favored.
REFERENCES:
patent: 3963691 (1976-06-01), Hoffman et al.
patent: 4218439 (1980-08-01), Rivier et al.
patent: 4263282 (1981-04-01), von der Ohe et al.
patent: 4302386 (1981-11-01), Stevens
patent: 4608251 (1986-08-01), Mia
patent: 4618598 (1986-10-01), Conn
patent: 4639512 (1987-01-01), Audibert et al.
patent: 4676981 (1987-06-01), Silversides et al.
Fraser et al., "Effect of Active Immunization to Luteinizing Hormone Releasing Hormone on Serum and Pituitary Gonadotropins, Testes and Accessory Sex Organs in the Male Rat" J. Endocr., vol. 63, pp. 399-406 (1974).
"Active Immunization Against LHRH in the Female" by I. A. Jeffcoate and B. J. Keeling, pp. 363-377 of Immunological Aspects of Reproduction in Mammals.
"Production and Characterization of an Antiserum to Synthetic Gonadotropin-Releasing Hormone" by Y. Koch et al., vol. 55, No. 3, of Biochemical and Biophysical Research Communications.
"A Method for Preparing Beta-hCG COOH Peptide-Carrier Conjugates of Predictable Composition" by A. C. J. Lee et al., pp. 749-756 of vol. 17 of Molecular Immunology by Pergamon Press, 1980.
Allen Anne F.
Mapletoft Reuben J.
Misra Vikram
Murphy Bruce D.
Silversides David W.
Brown Johnnie R.
Gil Joseph C.
University of Saskatchewan
Wessendorf T.
Whalen Lyndanne M.
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