Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1995-12-12
1999-06-08
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Lymphokine
424 852, 424 855, A61K 3819, A61K 3820, A61K 3821
Patent
active
059103035
ABSTRACT:
An agent which contains, as effective ingredients, interferon-.gamma. and a biologically active substance with either or both activities of promoting production of platelets and leukocytes. A small amount of the agent effectively promotes platelet and/or leukocyte production in mammals including humans without causing side effects.
REFERENCES:
patent: 5032396 (1991-07-01), Williams
patent: 5126325 (1992-06-01), Kishimoto et al.
patent: 5151265 (1992-09-01), Hwang-Felgner et al.
patent: 5178857 (1993-01-01), Goeth et al.
patent: 5358708 (1994-10-01), Patel
patent: 5472867 (1995-12-01), Kanz et al.
patent: 5556620 (1996-09-01), Ralph et al.
Weiner, L.M. et al "Tumor Immunology", Proceedings of Asso., vol. 12, Mar. 1993.
Shiohara M. et al. "Synergism of Interferon-Gamma and Stem Cell Factor on the Development of Murine Hematopoietic Progenitors in Serum-Free Culture", Blood, vol. 81, No. 6, Mar. 15, 1993 pp. 1435-1441.
Zoumbos N.C. et al. "Different Haematopoietic Growth Factors Have Different Capacity in Overcoming the in vitro Interferon Gamma-Induced Suppression of Bone Marrow Progenitor Cells", European Journal of Haematology vol. 44, No. 5, May 1990 pp. 282-290.
Barclay A.N. et al. "The Leucocyte Antigen Facts Book", 1992, Hartcourt Brace Jovanovich, London, p. 4, pp. 176-177.
Avraham, Hava. "Regulation of Megakaryocytopoiesis", Stem Cells, vol. 11, pp. 499-510 (1993).
Nand, Sucha, et al., "A Phase I/II Study of Sequential Interleukin-3 and Granuloycte-Macrophage Colony-Stimulating Factor in Myelodysplastic Syndromes", Blood, vol. 83, No. 2, pp. 357-360 (Jan. 15, 1994).
Ogawa, Makio. "Differentiation and Proliferation of Hematopoietic Stem Cells", Blood, vol. 81, No. 11, pp. 2844-2853 (Jun. 1, 1993).
Kishimoto, Tadamitsu. "The Biology of Interleukin-6", Blood, vol. 74, No. 1, pp. 1-10 (Jul. 1989).
Motoyoshi, Kazuo. "Hematopoietic growth factor (IL-3, G-CSF, GM-CSF, M-CSF, EPO)", The Third Department of Internal Medicine, National Defense Medical College, pp. 275-280 (1967), Abstract only.
Kanz, L. et al., "Hematopoietins in Clinical Oncology", Am. J. Clin. Oncol., vol. 14, suppl. 1, pp. S27-S33 (1991).
De Sauvage, Frederic et al., "Stimulation of Megakaryocytopoiesis and Thrombopoiesis by the C-Mpl Ligand", Nature, vol. 369, pp. 533-5338 (Jun. 16, 1994).
Wendling, Francoise et al., "C-Mpl Ligand is a Humoral Regulator of Megakaryocytpoiesis", Nature, vol. 369 pp. 571-574 (Jun. 16 1994).
Lok, Si et al., "Cloning and Expression of Murine Thrombopoietin cDNA and Stimulation of Platelet Production in vivo", Nature, vol. 369, pp. 565-574 (Jun. 16 1994).
Bartley, T.D. et al., "Identification and Cloning of a Megakaryocyte Growth and Development Factor that is a Ligand for the Cytokine Receptor Mpl", Cell, vol. 77, pp. 1117-1124 (Jul. 1, 1994).
Ganser, A. et al., "Effect of Long-Term Treatment with Recombinant Human Interleukin-3 in Patients with Myelodysplastic Syndromes", Leukemia, vol. 7, No. 5, pp. 696-701 (1993).
Kurzrock , Razelle. "Phase I of Study of Recombinant Human Interleukin-3 in Patients With Bone Marrow Failure", Journal of Clinical Oncology, vol. 9, No. 7, pp. 1241-1250 (Jul. 1991).
Mazur, Eric et al., "Megakaryocytopoiesis and Platelet Production: a Review", Exp. Hematol., vol. 15, pp. 340-350 (1987).
Hoffman, Ronald. "Regulation of Megakaryocytopoiesis", Blood, vol. 74, No. 4, pp. 1196-1212 (1989).
Kimura, Ikuro et al., "Hematological Toxicities of Cancer Chemotherapy", Toxicology Forum, vol. 11, No. 2, pp. 112-121 (1988).
Nakoinz et al. Stimulation of Macrophages Antibody-Dependent . . . Cellular Immunology. vol. 116, pp. 331-340, 1988.
Vassiliadis et al. "CSF-1 and Immune Interferon Synergize . . . " Leukemia Research, vol. 15, No. 10, pp. 943-942, 1991.
Muroshi et al., Interferon-.gamma. Enhances Growth Factor-Dependant in Blood, Aug. 15, 1991, vol. 78, No. 4, pp. 1085-1095.
Nagineni et al. Synergistic Effects of Gamma Interferon . . . Clin. Diagn. Lab. Immun. Sep. 1994, vol. 1, No. 5, pp. 569-577.
Almani et al. Abrogation of Glucocorticosteroid-Mediated Inhibition . . . J. Immunology, May 15, 1991, vol. 146, No. 10, pp. 3523-3527.
Brugger et al. Ex Vivo Expression of Enriched Peripheral Blood . . . Blood May 15, 1993, vol. 81, No. 10, pp. 2579-2584.
Caux et al. Interferon-.varies. Enhances Factor-Dependent Myeloid . . . Blood May 15, 1992, vol. 79, No. 10, pp. 2628-2635.
Maciejewski et al. Cytofluorometric and Cytomorphologic . . . Eur. J. Immunology, 1990, vol. 20, pp. 1209-1213.
Murohashi et al. Interferon-.varies. Enhances Growth Factor-Dependant . . . Blood Aug. 15, 19891, vol. 78, No. 4, pp. 1085-1095.
Magineni et al. Synergistic Effects of Gamma Interferon . . . Clin. Diag. Lab. Immun. Sep. 1994, vol. 1, No. 5, pp. 569-577.
Harashima Akira
Izumi Noboru
Kurimoto Masashi
Ohta Tsunetaka
Tahata Hiroyoshi
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Russel Jeffrey E.
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