Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1998-09-25
2000-04-25
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
A23K 116, A23K 118
Patent
active
060544910
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/SE97/00488 filed Mar. 21, 1997.
The present invention relates to an agent for increasing the production of/in breeding and production mammals, to a method of increasing the production with said agent and the use of said agent. The agent consists of at least one type of xanthophylles, preferably naturally produced astaxanthin. It is administered in the feed to breeding and production animals to obtain increased production thereof.
BACKGROUND
In the food, livestock, breeding animal and domestic animal industry the production of/in breeding and production animals is of great importance to the economy. Hence, there is a demand for agents that increase the productivity by for example improved fertility, more progeny born alive (especially pig, cow and sheep), lower mortality after birth, increased growth during the sucking period, higher milk production, shorter recovery period between weaning and new heat, and generally improved state of health due to strengthened immune defence.
The present invention now provides such an agent, which consists of at least one type of xanthophylles, preferably naturally produced astaxanthin
Astaxanthin belongs to the xanthophylles, which is a large group of carotenoids containing oxygen in the molecule in addition to carbon and hydrogen. The carotenoids are produced de novo by plants, fungi and some bacteria.
Xanthophylles have since long been used in the feed for laying hens and in some parts of the world in the feed for broilers, but not in the feed for breeding or production mammals. The purpose has solely been to pigment the product, the yolk or fat and skin tissue, to satisfy the demands of the consumers. As sources for pigment both naturally produced xanthophylles and synthetically produced ones have been used (Hencken H., 1992, Poultry Science 71:711-717, Karunajeewa H. & A. Hoffman, 1992, Arch fur Geflugeikunde 56(3):109-112).
Thus, it has not previously been known that xanthophylles, and among them astaxanthin, have the ability to increase the production of/in breeding and production mammals.
The reason for the improved productivity when astaxanthin enriched feed is used according to the present invention is not known, but it can be assumed to be due to the antioxidative properties of astaxanthin, and hence the ability to scavenge so-called free radicals. The other xanthophylles do also have antioxidative properties. However, in biological tests astaxanthin has been shown to possess clearly the best antioxidative properties compared to other carotenoids (Miki W., 1991, Pure and Appl Chem 63 (1): 141-146).
DESCRIPTION OF THE INVENTION
The present invention thus provides an agent for increasing the production of/in breeding and production mammals, which agent consists of at least one type of xanthophylles.
Examples of breeding and production mammals are pigs, cattle, sheep, horses, dogs etc.
In a preferred embodiment the type of xanthophylles is astaxanthin. In a particularly preferred embodiment the astaxanthin exists in a form in which it is esterified with fatty acids. The last mentioned form of astaxanthin may be produced by cultivation of the alga Haematococcus sp.
The agent according to the invention may consist of a mixture of different types of xanthophylles or different forms of the same xanthophyll, such as a mixture of synthesized astaxanthin and naturally produced astaxanthin.
The present invention further provides a method of increasing the production of/in breeding and production mammals, in which an agent, which consists of at least one type of xanthophylles, is administered in the feed to said mammals.
In an embodiment of said method the type of xanthophyll is preferably astaxanthin. In a preferred embodiment of said method according to the invention, astaxanthin which exists in the form esterified with fatty acids, is administered. The amount of agent administered is suitably in the range of 1 to 50 mg agent per kg feed.
The present invention further comprises the use of an agent which consists of at least one type
REFERENCES:
patent: 5744502 (1998-04-01), Lignell et al.
Inborr Johan
Lignell .ANG.ke
Astacarotene AB
Spivack Phyllis G.
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