Agent for enhancing antitumor activity of antitumor agent

Details Agent for enhancing antitumor activity of antitumor agent Agent for enhancing antitumor activity of antitumor agent

1983-05-27

1986-12-09

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514211, 514281, 424 10, A61K 3170, A61K 3155, A61K 3144

Patent

active

046280472

ABSTRACT:
An agent for enhancing antitumor activity of antitumor agents comprising as the active ingredient diltiazem or a pharmaceutically acceptable acid addition salt thereof, an antitumor composition comprising the diltiazem or an acid addition salt thereof and a conventional antitumor agent, and further a method for treating tumors by administering diltiazem or an acid addition salt thereof together with a conventional antitumor agent in oral or parenteral route to patients suffering from various tumors. Said active diltiazem or a salt thereof is effective for enhancing the antitumor activity of antitumor agents because it can enhance sensitivity of tumor cells to antitumor agents regardless the tumor cells have resistance to the antitumor agents or not.

REFERENCES:
Chemical Abstracts 99:16207c (1983).
Chemical Abstracts 99:205713a (1983).
The Merck Index, 9th Edition, Monograph 3187.
The Extra Pharmacopoeia, Martindale, 27th Edition, p. 1750.

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