Agent for dehydrating corneas in organ culture

Details Agent for dehydrating corneas in organ culture Agent for dehydrating corneas in organ culture

1999-07-23

2000-12-19

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

435 11, 435 12, 435 13, 436 18, 536128, C12N 500, A01N 100, A01N 102, G01N 3100, C07H 106

Patent

active

061626422

ABSTRACT:
An agent for dehydrating corneas, in particular eye corneas for organ culture, contains the culture medium and as dehydrating substance hydroxyethylstarch with a mean molecular weight Mw from 070,000 to 200,000, an MS substitution degree from 0.15 to 0.5, a DS substitution degree from 0.15 to 0.5 and a C2-C6 substitution ratio at the anhydroglucose units .ltoreq.8. The dehydrating substance is preferably hydroxyethylstarch with a mean molecular weight Mw 130,000.+-.20,000, an MS substitution degree from 0.38 to 0.45, a DS substitution degree from 0.32 to 0.40 and a C2-C6 substitution ratio at the anhydroglucose units from 8 to 20. The hydroxyethylstarch is used in a concentration from 1 to 20 (weight/vol.) %, preferably from 2 to 15 (weight/vol.) %, and in particular of 7.5% (weight/vol.). Also disclosed is the use of this hydroxyethylstarch as a dehydrating substance for the organ culture of corneas, in particular eye corneas, and the use of this hydroxyethylstarch for preparing a dehydrating agent for corneas, in particular eye corneas for organ culture.

REFERENCES:
patent: 5306711 (1994-04-01), Andrews
patent: 5502043 (1996-03-01), Weidler et al.
Walkenbach et al., Current Eye Research, vol. 10, 12, pp 1129-1136. The effects of UW solution and its components on corneal thickness during and after storage, 1991.

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