Method of protecting brain tissue from cerebral infarction subse

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 3170

Patent

active

058011609

ABSTRACT:
Methods and pharmaceutical compositions for reducing the extent of infarction, particularly cerebral infarction subsequent to cerebral ischemia.

REFERENCES:
patent: 4386077 (1983-05-01), Borgo
patent: 4386078 (1983-05-01), Horrocks et al.
The Ancrod Stoke Study Investigators, Ancrod for the Treatment of Acute Ischemic Brain Infarction Stroke. 1994,25:1755-1759.
Bell et al., A Novel Treatment for Ischemic Intracranial Hypertension in Cats. Stroke. 1991 22:80-83.
del Zoppo et al., Thrombolytic Intervention in Acute Thrombotic and Embolic Stroke. Seminars in Neurology. 1991 11/4;368-384.
Diener et al., The Effect of Lubelezole in the Acute Treatment of Ischemic Stroke: Results of a Phase 2 Trail Stroke. 1995 26:30.
Hacke et al., The Efficacy of IV-tPA in Acute Ischemic Stroke; First Results of the ECASS Trail Stroke. 1995 26:167.
Kaste et al., A Randomized, Double-blind, Placebo-Controlled Trail of Nimodipine in Acute Ischemic Hemispheric Stroke. Stroke. 1994 25:1348-1353.
Kinouchi et al., Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc. Natl. Acad. Sci. USA. 1991 88:11158-11162.
Minematsu et al., Diffusion weighted magnetic resonance imaging: Rapid and quantitative detection of focal brain ischemia. Neurology 1992 42:235-240.
Olney et al., NMDA Antagonist Neurotoxicity: Mechanism and Prevention. Science 1991 254:1515-1518.
Ulus et al., Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum. Brain Research 1989 484:217-227.
Zea Longa et al., Reversible Middle Cerebral Artery Occulsion Without Craniectomy in Rats. Stroke 1989 20:84-91.
Windholtz et al. (eds.), The Merck Index, 19.sup.th Ed., Merck & Co., Inc. Rahway, NJ, 1983, entry 2290 at p. 329.
Makishima et al., "Treatment of Sensory-Neural Deafness and Tinnitus with a Nucleic Acid Derivative," Arzeneimittel Forsch. Dtsh., 21,(9),1343-1349 (1971).
Nilsson, "CDP-Choline-A Short Review," Clin. Pharmacol. Drug Epidemiol. 2,273-277 (1979).
Phuong et al., "Nouvell Methode de Preparation de al Cytidine Diphosphate Choline (CDP Choline)", Bull. Soc. Chim. Fr. Pt. II., 1979(9-10), 518-519.
Gannaro et al. (eds.), Remmington's Pharmaceutical Sciences, 18.sup.th ed., Mack Publishing Co., Easton, PA, 1990, see pp. 867, 1014 and 1026 as marked.
Sanchez et al., "CDP-Choline:Physico-Chemical Characteristics," Arzneimittel Forschung-Drug Research, 33(II), 1011-1012(1983).
Algate et al., "Study of the Effects of Oral Administration of CDP-Choline on EEG Changes and Lethality Induced by Epidural Compressions in the Anaethestized Cat." Arzneimittel Forschung-Drug Research, 33(II), 1013-1016(1983).
Agut et al.(I), "Dissimilar Effects in Acute Toxicity Studies of CDP-Choline and Choline," Arzneimittel Forschung-Drug Research, 33(II), 1016-1018(1983).
Braso et al., "Action of CDP-Choline by Intraduodenal Route on Rat Cardiorespitory System," Arzneimittel Forschung-Drug Research, 33(II), 1043-1045 (1983).
Agut et al.(II, "Bioavailability of Methyl-.sup.14 C CDP-Choline and Choline by Oral Route." Arzneimittel Forschung-Drug Research, 33(II), 1045-1047(1983).
Agut et al. (III), "Radioactivity Incorporation into Different Cerebral Phospholipids after Oral Administration of .sup.14 C Methyl CDP-Choline," Arzneimittel Forschung-Drug Research, 33(II), 1048-1050 (1983).
Aguilar et al., "Cerebral Subcellular Distribution of CDP-Choline and/or its Metabolites after Oral Administration of Methyl-.sup.14 C CDP-Choline," Arzneimitel Forschung-Drug Research, 33(II), 1051-1053(1983).
Romero et al.(I), "Low-Resolution Autoradiography in Rat Brain after Administering Labeled CDP-Choline Administration," Arzeimittel Forschung-Drug Research, 33(II), 1054-1056(1983).
Romero et al.(II), "High-Resolution Autoradiography in Mouse Brain 24 h after Radiolabelled CDP-Choline Administration," Arzeimittel Forschung-Drug Research, 33(II), 1056-1058(1983).
Romero et al.(III), "High-Resolution Autoradiography in Mouse Brain and Cerebellum 10 days after Radiolabelled CDP-Choline Administration," Arzneimittel Forschung-Drug Research, 33(II), 1058-1060(1983).
Dinsdale et al. (I), "CDP-Choline: Repeated Oral Dose Tolerance Studies in Adult Healthy Volunteers," Arzneimittel Forschung-Drug Research, 33(II), 1061-1065(1983).
Arrannz et al. "Treatment of Chronic Dyskinesia with CDP-Choline," Arzneimittel Forschung-Drug Research, 33(II), 1071-1073(1983).
Tornos et al. (I), "Effect of Oral CDP-Choline on Experimental Withdrawal Syndrome," Arzeimittel Forschung-Drug Research, 33(II), 1018-1021 (1983).
Tornos et al. (II), "Pharmacological Study of CDP-Choline," Arzneimittel Forschung-Drug Research, 33(II), 1022-1024(1983).
Grau et al.(1), "Study on the Protection of CDP-Choline against Nicotine Intoxification," Arneimittel Forschung-Drug Research, 33(II), 1025-1026(1983).
Tornos et al. (III), "Pharmacological Study of Oral CDP-Choline," Arzneimittel Forschung-Drug Research, 33(II), 1026-1029(1983).
Agut et al. (IV), "Effect of Oral CDP-Choline on Acrylamide-induced Lesion." Arzeimittel Forschung-Drug Research, 33(II), 1029-1033(1983).
Grau et al. (II), "CDP-Choline: Acute Toxicity Study," Arzneimittel Forschung-Drug Research, 33(II), 1033-1034(1983).
Romero et al.(IV), "Study of Subacute Toxicity of CDP-Choline after 30 days of Oral Administration to Rates," Arzneimittel Forschung-Drug Research, 33(II), 1035-1038(1983).
Romero et al. (V), "CDP-Choline: 6-Month Study on Toxicity in Dogs," Arzneimittel Forschung-Drug Research, 33(II), 1038-1042(1983).
Dinsdale et al. (II), "Pharmacokinetics of .sup.14 C CDP-Choline," Arzneimittel Forschung-Drug Research, 33(II), 1066-1070(1983).
Fernandez, "Efficacy and Safety of Oral CDP-Choline," Arzneimittel Forschung-Drug Research, 33(II), 1073-1080(1983).
Table of Contents, Key Word Index and Prefacea.sup.a (J.A. Ortiz) Introducing the Series of Papers on Cytidine Diphosphate Choline, Arzneimittel Forschung-Drug Research, 33(II), 1009-1010a.sup.a (1983) and preceding pages.
Cohen et al., "Decreased Brain Choline Uptake in Older Adults-An In Vivo Proton Magnetic Resonance Spectroscopy Study," J. Am. Medical Association, 274(11),902-907 (1995).
Fukunaga et al. (I), "Hypotensive Effects of Adenosine and Adenosine Triphosphate Compared with Sodium Nitroprusside," Anesthesia and Analgesia, 61(3), 273-278 (1982).
Trovarelli, G. et al., "Effect of Cytidine on the Modification of Phospholipid Metabolism Induced by Ischemia", Neurochemical Research, vol. 12, No. 3, 1987, pp. 227-235.
Trovarelli, G. et al., "The Influence of Cytidine on the Endogenous Pool of CDP-Choline, CDP-Ethanolamine, and CMP of the Rat Brain", Neurochemical Research, vol. 9, No. 1, 1984, pp. 73-79.
Trovarelli, G. et al., "The Transport of Cytidine into Rat Brain In Vivo, and its Conversion into Cytidine Metabolites", Neurochemical Research, vol. 7, No. 10, 1982, pp. 1199-1207.
De Medio, G.E. et al., "The Effect of Cytidine-Diphosphate Choline (CDP-Choline) on Brain Lipid Changes During Aging", Journal of Neuroscience Research, 11:49-58 (1984).
Petkov, V.D. et al., "Effects of Cytidine Diphosphate Choline on Rats with Memory Deficits", Institute of Phisiology, Bulgarian Academy of Science, Sofia, Bulgaria, Arzneim.-Forsch/Drug Res. 43(II), Nr. 8 (1993).
Kottler, P.D. et al., "RNA Metabolism in the Rat Brain During Learning Following Intravenous and Intraventricular Injections of 3H-Cytidine", Physiology and Behavior, vol. 8, pp. 291-297 (1992).
Wurtman, R.J. et al., "The `Autocannibalism` of Choline-Containing Membrane Phospholipids in the Pathogenesis of Alzheimer's Disease", Dept. of Applied Biological Sciences, Cambridge, MA, USA and Pharmacology Department, Universite, Suisse, 1990.
Buyukuysal, R.L. et al., "4-Aminopyridine Increases Acetylcholine Release Without Diminishing Membrane Phosphatidylcholine", Journal of Neurochemistry, vol. 54, No. 4, 1990, pp. 1302-1309.
Savci, V. et al., "Effect of Cytidine on Membrane Phospholipid Synthesis in Rat Striatal Slices", Journal of Neurochemistry, vol. 64, No. 1, 1995, pp. 378-384.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of protecting brain tissue from cerebral infarction subse does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of protecting brain tissue from cerebral infarction subse, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of protecting brain tissue from cerebral infarction subse will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-270376

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.