Aerosol actuator providing increased respirable fraction

Details Aerosol actuator providing increased respirable fraction Aerosol actuator providing increased respirable fraction

1990-08-31

1992-05-26

Burr, Edgar S.

Surgery

Liquid medicament atomizer or sprayer

Pre-pressurized container holding medicament

12820315, A61M 1500

Patent

active

051158035

ABSTRACT:
An actuator for use in inhalation therapy comprising a nozzle block having an orifice and at least one bleed hole, a conduit chamber, a deagglomeration chamber, and an exit chamber, together configured as a means for increasing the respirable fraction of an aerosol formulation. This invention also provides an actuator as described above in combination with an aerosol canister comprising a pharmaceutical formulation, and a method of administering a pharmaceutical formulation via inhalation therapy. The actuator finds particular use in improving the respirable fraction of drug in aerosol formulations. The actuator also retains non-respirable particles, thus reducing the amount of drug that is inadvertently administered orally.

REFERENCES:
patent: 1263079 (1918-04-01), Leon
patent: 2546214 (1951-03-01), Curry
patent: 2582529 (1952-01-01), Curry et al.
patent: 2585429 (1952-02-01), Boe
patent: 2865370 (1958-12-01), Gattone
patent: 3107670 (1962-03-01), Silson et al.
patent: 3236458 (1966-02-01), Ramis
patent: 3610480 (1971-10-01), Lippert
patent: 3838686 (1974-10-01), Szekely
patent: 4940051 (1990-07-01), Lankinen
patent: 4953545 (1990-09-01), McCarty

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