Aerodynamically light particles for pulmonary drug delivery

Details Aerodynamically light particles for pulmonary drug delivery Aerodynamically light particles for pulmonary drug delivery

2005-09-13

2005-09-13

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

C424S009100, C424S445000, C424S489000

Reexamination Certificate

active

06942868

ABSTRACT:
Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm3and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

REFERENCES:
patent: 2470296 (1949-05-01), Fields
patent: 2533065 (1950-12-01), Taplin, et al.
patent: 2992645 (1961-07-01), Fowler
patent: 3781230 (1973-12-01), Vassiliades, et al.
patent: 3957965 (1976-05-01), Hartley et al.
patent: 4009280 (1977-02-01), Macarthur et al.
patent: 4089800 (1978-05-01), Temple
patent: 4161516 (1979-07-01), Bell
patent: 4173488 (1979-11-01), Vassiliades et al.
patent: 4272398 (1981-06-01), Jaffe
patent: 4352883 (1982-10-01), Lim
patent: 4391909 (1983-07-01), Lim
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4524769 (1985-06-01), Wetterlin
patent: 4572203 (1986-02-01), Feinstein
patent: 4590206 (1986-05-01), Forrester et al.
patent: 4615697 (1986-10-01), Robinson
patent: 4679555 (1987-07-01), Sackner
patent: 4741872 (1988-05-01), De Luca et al.
patent: 4743545 (1988-05-01), Torobin
patent: 4774958 (1988-10-01), Feinstein
patent: 4789550 (1988-12-01), Hommel et al.
patent: 4818542 (1989-04-01), De Luca et al.
patent: 4847091 (1989-07-01), Illum
patent: 4855144 (1989-08-01), Leong et al.
patent: 4857311 (1989-08-01), Domb et al.
patent: 4861627 (1989-08-01), Mathiowitz et al.
patent: 4865789 (1989-09-01), Castro et al.
patent: 4904479 (1990-02-01), Illum
patent: 4917119 (1990-04-01), Potter et al.
patent: 4976968 (1990-12-01), Steiner
patent: 4994281 (1991-02-01), Muranishi et al.
patent: 5033463 (1991-07-01), Cocozza
patent: 5064650 (1991-11-01), Lew
patent: 5069936 (1991-12-01), Yen
patent: 5075109 (1991-12-01), Tice et al.
patent: 5100669 (1992-03-01), Hyon et al.
patent: 5123414 (1992-06-01), Unger
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5160745 (1992-11-01), De Luca et al.
patent: 5169871 (1992-12-01), Hughes et al.
patent: 5195520 (1993-03-01), Schlief et al.
patent: 5204108 (1993-04-01), Illum
patent: 5204113 (1993-04-01), Hartley et al.
patent: 5260306 (1993-11-01), Boardman et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5306483 (1994-04-01), Mautone
patent: 5327883 (1994-07-01), Williams et al.
patent: 5334381 (1994-08-01), Unger
patent: 5352435 (1994-10-01), Unger
patent: 5384133 (1995-01-01), Boyes et al.
patent: 5393524 (1995-02-01), Quay
patent: 5407609 (1995-04-01), Tice et al.
patent: 5456917 (1995-10-01), Wise et al.
patent: 5482946 (1996-01-01), Clark et al.
patent: 5518709 (1996-05-01), Sutton et al.
patent: 5518998 (1996-05-01), Bäckström et al.
patent: 5551489 (1996-09-01), Trofast et al.
patent: 5607695 (1997-03-01), Ek et al.
patent: 5612053 (1997-03-01), Baichwal et al.
patent: 5674471 (1997-10-01), Akehurst et al.
patent: 5690954 (1997-11-01), Illum
patent: 5707644 (1998-01-01), Illum
patent: 5795594 (1998-08-01), York et al.
patent: 5804212 (1998-09-01), Illum
patent: 5814607 (1998-09-01), Patton
patent: 5830853 (1998-11-01), Bäckström et al.
patent: 5851453 (1998-12-01), Hanna et al.
patent: 5855913 (1999-01-01), Hanes et al.
patent: 5874064 (1999-02-01), Edwards et al.
patent: 5985309 (1999-11-01), Edwards et al.
patent: 6063138 (2000-05-01), Hanna et al.
patent: 6136295 (2000-10-01), Edwards et al.
patent: RE37053 (2001-02-01), Hanes et al.
patent: 6254854 (2001-07-01), Edwards et al.
patent: 6399102 (2002-06-01), Edwards et al.
patent: 6436443 (2002-08-01), Edwards et al.
patent: 2085884 (1992-01-01), None
patent: 1300009 (1992-05-01), None
patent: 1302258 (1992-06-01), None
patent: 2111002 (1992-12-01), None
patent: 2126244 (1993-06-01), None
patent: 2166108 (1995-01-01), None
patent: 2170394 (1995-03-01), None
patent: 2058428 (2000-09-01), None
patent: 0 072 046 (1983-02-01), None
patent: 0 213 303 (1986-06-01), None
patent: 0 257 915 (1988-03-01), None
patent: 0 324 938 (1989-07-01), None
patent: 0 335 133 (1989-10-01), None
patent: 0 458 745 (1991-05-01), None
patent: 0 257 956 (1992-05-01), None
patent: 0 510 731 (1992-10-01), None
patent: 0 634 166 (1995-01-01), None
patent: 0 656 206 (1995-06-01), None
patent: 1 288 583 (1969-11-01), None
patent: WO 92/18164 (1962-10-01), None
patent: WO 80/02365 (1980-11-01), None
patent: WO 88/04556 (1988-06-01), None
patent: WO 88/09163 (1988-12-01), None
patent: WO 91/04732 (1991-04-01), None
patent: WO 91/06286 (1991-05-01), None
patent: WO 91/06287 (1991-05-01), None
patent: WO 91/12823 (1991-09-01), None
patent: WO 92/21382 (1992-12-01), None
patent: WO 93/25221 (1993-12-01), None
patent: WO 94/04133 (1994-03-01), None
patent: WO 94/07514 (1994-04-01), None
patent: WO 94/08627 (1994-04-01), None
patent: WO 94/16739 (1994-04-01), None
patent: WO 95/00127 (1995-01-01), None
patent: WO 95/07072 (1995-03-01), None
patent: WO 95/24183 (1995-09-01), None
patent: WO 95/35097 (1995-12-01), None
patent: WO 96/09814 (1996-04-01), None
patent: WO 96/15814 (1996-05-01), None
patent: WO 96/23485 (1996-08-01), None
patent: WO 97/36574 (1997-10-01), None
patent: WO 99/16419 (1999-04-01), None
patent: WO 99/16420 (1999-04-01), None
patent: WO 99/16421 (1999-04-01), None
patent: WO 99/16422 (1999-04-01), None
Clay, et al. “Effect of aerosol particle size on bronchodilation with nebulized terbutaline in asthmatic subjects,”Thorax, 41:364-368 (1986).
Cohen, et al., “Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) Microspheres,”Pharm. Res., 8(6):713-720 (1991).
Daly, et al., “The Preparation of N-Carboxyanhydrides of α-Amino Acids Using Bis(Trichloromethyl) Carbonate,”Tetrahedron Lett., 29:5859 (1988).
Damms and Bains, “The Cost of Delivering Drugs without Needles,”J. Controlled Release, 8-11 (1996).
Davies, et al., “Breathing of half-micron aerosols. I. Experimental.,”J. Appl. Physiol., 32:591-600 (1972).
Dorries and Valberg, “Heterogeneity of phagocytosis for inhaled versus instilled material,”Am. Rev. Resp. Disease, 146:831-837 (1991).
Doubrow, Ed., “Microcapsules and Nanopartaicles,Medicine and Pharmacy,” CRC Press, Boca Raton, 1992.
Edwards, “The macrotransport of aerosol particles in the lung: Aerosol deposition phenomena,”J. Aerosol Sci., 26:293-317 (1995).
Eldridge, et al., “Biodegradable microspheres as a vaccine delivery system,”Mol. Immunol., 28:287-294 (1991).
Findeisen, “Uber das Absetzen kleiner in der Luft suspendierter Teilchen in der menshlichen Lunge bei der Atmung,”Pflugers Arch. D. Ges. Physiol., 236: 367-379 (1935).
French, Edwards, and Niven, “The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation,”J. Aerosol Sci., 27:769-783 (1996).
Ganderton, “The generation of respirable clouds from coarse powder aggregates,”J. Biopharmaceutical Sciences, 3:101-105 (1992).
Gehr, et al., “Surfactant and inhaled particles in the conducting airways: Structural, stereological, and biophysical aspects,”Microscopy Res. And Tech., 26:423-436 (1993).
Gerrity, et al., :Calculated deposition of inhaled particles in

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